T5050
Transforming Growth Factor-β1 from porcine platelets
≥97% (SDS-PAGE), recombinant, powder, suitable for cell culture
Synonym(s):
TGF-β1
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About This Item
Biological source:
Porcine (Platelets)
Assay:
≥97% (SDS-PAGE)
Form:
powder
Mol wt:
protein 25 kDa
Impurities:
≤1 EU/μg
Product Name
Transforming Growth Factor-β1 from porcine platelets, TGF-β1, powder, suitable for cell culture
biological source
Porcine (Platelets)
Quality Segment
assay
≥97% (SDS-PAGE)
form
powder
potency
0.01-0.1 ng/mL ED50/EC50
quality
endotoxin tested
mol wt
protein 25 kDa
packaging
pkg of 1 μg, pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
≤1 EU/μg
UniProt accession no.
storage temp.
−20°C
General description
Application
Transforming Growth Factor-β1 from porcine platelets has been used in chondrogenic differentiation. It has also been used in immobilization process.
Biochem/physiol Actions
Transforming growth factor-β1 (TGF-β) is a multifunctional polypeptide growth factor. TGF-β mediates cell proliferation, differentiation and migration. Important cellular functions such as inflammation, extracellular matrix synthesis, epithelial restoration and developmental processes are also controlled by TGF-β. TGF-β controls the regulation of enamel mineralization in porcine. TGF-β is associated with the development of idiopathic pulmonary fibrosis (a chronic lung disease). TGF-β promotes epithelial-mesenchymal transition (EMT) and contributes to proliferation and metastasis of cancer. The TGF-β induced EMT is observed in kidney fibrosis. TGF-β is stimulates regeneration of intestinal tissue.
Transforming growth factor-β1 (TGF-β1) is produced by many cell types, but is reported to be most concentrated in mammalian platelets, where it is present at approximately four times the level of TGF-β2.
Physical form
Lyophilized from a 0.2 μm filtered solution in 35% acetonitrile and 0.1% trifluoroacetic acid containing 0.05 mg bovine serum albumin per μg cytokine.
Analysis Note
The biological activity is measured by its ability to inhibit the IL-4-dependent proliferation of mouse HT-2 cells.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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