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Merck
CN

T5080

Thymulin

lyophilized powder

Synonym(s):

Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH trifluoroacetate salt, STF, Serum Thymic Factor

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About This Item

Empirical Formula (Hill Notation):
C33H54N12O15
CAS Number:
Molecular Weight:
858.85
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
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biological source

synthetic (organic)

assay

97-100% (HPLC)

form

lyophilized powder

color

white

solubility

deionized water: soluble

shipped in

dry ice

storage temp.

−20°C

SMILES string

C[C@H](NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(O)=O

InChI

1S/C33H54N12O15/c1-15(39-29(55)18-6-8-24(50)40-18)27(53)42-16(4-2-3-9-34)30(56)45-21(14-47)32(58)43-17(5-7-22(35)48)28(54)38-11-25(51)37-12-26(52)41-20(13-46)31(57)44-19(33(59)60)10-23(36)49/h15-21,46-47H,2-14,34H2,1H3,(H2,35,48)(H2,36,49)(H,37,51)(H,38,54)(H,39,55)(H,40,50)(H,41,52)(H,42,53)(H,43,58)(H,44,57)(H,45,56)(H,59,60)/t15-,16-,17-,18-,19-,20-,21-/m0/s1

InChI key

LIFNDDBLJFPEAN-BPSSIEEOSA-N

Application

Thymulin was used to study the impact of this compound on gonadotrophin-induced ovulation and on onset of puberty in mice.

Biochem/physiol Actions

Thymulin also refers as serum thymic factor is a nonapeptide that reduces the hyperalgesia induced due to peripheral endotoxin administration in rats and mice. It also possesses an immunomodulator function by regulating the cytokine production by peripheral blood mononuclear cells (PBMC).
Thymulin, also known as Thymic Factor, is a nonapeptide produced by epithelial cell popuation in the thymus. This peptide is known for its immunomodulatory role and has neuroendocrine effects as well.

Physical form

Lyophilized from 0.1% aqueous TFA.

Other Notes

Lyophilized from 0.1% TFA in H2O


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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