T5443
Tyrphostin AG 825
≥92.5%
Synonym(s):
5-[(Benzothiazol-2-yl)thiomethyl]-4-hydroxy-3-methoxybenzylidenecyanoacetamide, Tyrphostin C15
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About This Item
Empirical Formula (Hill Notation):
C19H15N3O3S2
CAS Number:
Molecular Weight:
397.47
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥92.5%
Form:
powder
Quality Segment
assay
≥92.5%
form
powder
solubility
DMSO: soluble, methanol: soluble
storage temp.
−20°C
SMILES string
COc1cc(cc(CSc2nc3ccccc3s2)c1O)\C=C(/C#N)C(N)=O
InChI
1S/C19H15N3O3S2/c1-25-15-8-11(6-12(9-20)18(21)24)7-13(17(15)23)10-26-19-22-14-4-2-3-5-16(14)27-19/h2-8,23H,10H2,1H3,(H2,21,24)/b12-6+
InChI key
KXDONFLNGBQLTN-WUXMJOGZSA-N
Application
Tyrphostin AG 825 has been used to study its effects on iodide uptake in EMT6 cells1.
Biochem/physiol Actions
EGF receptor tyrosine kinase inhibitor, inactive against IGF-1 Receptor.
Tyrphostin AG 825 has been used in combination with hypericin-mediated photodynamic therapy (HY-PDT) for evaluating its therapeutic effects in HER2 overexpressing human breast cancer cells. This study reported that AG 825 combination increased the induction of cell death, HER2 degradation and inhibited colony formation in cancer cells2.
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Preparation Note
Tyrphostin AG 825 is soluble in DMSO and methanol.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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