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T5568

Tyrphostin AG 835

≥92%

Synonym(s):

(+)-(S)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide, Tyrphostin B50

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About This Item

Empirical Formula (Hill Notation):
C18H16N2O3
CAS Number:
Molecular Weight:
308.33
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
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assay

≥92%

form

crystalline

potency

IC50 (860 nanomolar for the inhibition of EGFR-kinase activity.)

solubility

DMSO or ethanol: soluble

storage temp.

−20°C

SMILES string

C[C@H](NC(=O)\C(=C\c1ccc(O)c(O)c1)C#N)c2ccccc2

InChI

1S/C18H16N2O3/c1-12(14-5-3-2-4-6-14)20-18(23)15(11-19)9-13-7-8-16(21)17(22)10-13/h2-10,12,21-22H,1H3,(H,20,23)/b15-9+/t12-/m0/s1

InChI key

UMGQVUWXNOJOSJ-DGGAMASNSA-N

Biochem/physiol Actions

Protein tyrosine kinase inhibitor.

Preparation Note

Tyrphostin AG 835 is soluble in ethanol and DMSO.


Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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