T5694
TRAIL human
recombinant, expressed in NSO cells, >97% (SDS-PAGE), lyophilized powder
Synonym(s):
Apo2 Ligand, Apo2L, TL2, TNF-related apoptosis-inducing ligand
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About This Item
Form:
lyophilized powder
Assay:
>97% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in NSO cells
Mol wt:
24 kDa by SDS-PAGE, predicted mol wt ~21 kDa
biological source
human
Quality Segment
recombinant
expressed in NSO cells
description
N-terminal 6X histidine-tagged extracellular domain
assay
>97% (SDS-PAGE)
form
lyophilized powder
mol wt
24 kDa by SDS-PAGE, predicted mol wt ~21 kDa
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... TNFSF10(8743)
Application
TRAIL human was used to induce cytotoxicity in A549, a human lung carcinoma cell line.
Biochem/physiol Actions
TNF-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane protein that belongs to TNF family. It is present in both soluble as well as membrane-bound form and can induce rapid apoptosis of various transformed cell lines but not the normal cells. Additionally, the product can also induces apoptotic cell death in TRAIL-sensitive U343MGcells.
Type II transmembrane protein of the TNF superfamily. Ligand for apoptosis-inducing death receptors DR4 and DR5, decoy receptors DcR1 and DcR2, and osteoprotegerin. Approximately 28% amino acid sequence identity to FAS ligand. Human and mouse TRAIL share 65% sequence identity.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.
Analysis Note
Induces cytotoxicity in mouse L-929 cells in the presence of actinomycin D.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
常规特殊物品
低风险生物材料
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| T5694-10UG | 04061833236987 |