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Merck
CN

T6140

N-(p-Tosyl)-Gly-Pro-Lys 4-nitroanilide acetate salt

plasmin substrate, chromogenic, ≥98% (TLC), powder

Synonym(s):

N-Tosylglycyl-L-prolyl-L-lysine 4-nitroanilide acetate salt

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About This Item

Linear Formula:
C26H34N6O7S · C2H4O2
CAS Number:
88793-79-7
Molecular Weight:
634.70
NACRES:
NA.32
PubChem Substance ID:
24900352
UNSPSC Code:
12352204
EC Number:
289-446-7
MDL number:
MFCD00057232

Key Documents

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Product Name

N-(p-Tosyl)-Gly-Pro-Lys 4-nitroanilide acetate salt, plasmin substrate

InChI key

KPGSNEYSJPIZCW-SJEIDVEUSA-N

InChI

1S/C26H34N6O7S.C2H4O2/c1-18-7-13-21(14-8-18)40(38,39)28-17-24(33)31-16-4-6-23(31)26(35)30-22(5-2-3-15-27)25(34)29-19-9-11-20(12-10-19)32(36)37;1-2(3)4/h7-14,22-23,28H,2-6,15-17,27H2,1H3,(H,29,34)(H,30,35);1H3,(H,3,4)/t22-,23-;/m0./s1

SMILES string

CC(O)=O.Cc1ccc(cc1)S(=O)(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)Nc3ccc(cc3)[N+]([O-])=O

assay

≥98% (TLC)

form

powder

solubility

ethanol: 50 mg/mL, colorless to yellow

storage temp.

−20°C

Quality Level

200

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Application

N-(p-Tosyl)-Gly-Pro-Lys 4-nitroanilide acetate salt has been used:
  • as a substrate for examining the amidolytic activity of aprE2, aprE5-41
  • as a substrate for serine protease and fibrinogenolytic assays
  • as a substrate for plasmin assay

Biochem/physiol Actions

N-(p-Tosyl)-Gly-Pro-Lys 4-nitroanilide acetate salt is a chromogenic substrate for plasmin assay, serine protease enzyme activity and fibrinogenolytic assays.

General description

A chromogenic substrate for plasmin.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL0306
BCCL4875
BCCG5736
BCCF8398
BCCD4452

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Min Wang et al.
International journal of biological macromolecules, 146, 781-789 (2019-11-16)
The heterologous nature of SAK, a thrombolytic drug, elicits high titers of neutralizing antibodies, which limits its clinical use. Here, we aim to establish a SAK mutant with equivalent activity to the wild type but reduced antigenicity, which may allow
Overexpression of aprE2, a Fibrinolytic Enzyme Gene from Bacillus subtilis CH3-5, in Escherichia coli and the Properties of AprE2.
Jeong SJ, et al.
Journal of microbiology and biotechnology, 24(7), 969-978 (2014)
Streptococcus pneumoniae choline-binding protein E interaction with plasminogen/plasmin stimulates migration across the extracellular matrix.
Attali C, et al.
Infection and Immunity, 76(2), 466-476 (2008)
Michał Śmiga et al.
BMC microbiology, 19(1), 127-127 (2019-06-13)
Porphyromonas gingivalis is considered a keystone pathogen responsible for chronic periodontitis. Although several virulence factors produced by this bacterium are quite well characterized, very little is known about regulatory mechanisms that allow different strains of P. gingivalis to efficiently survive
Purification and characterization of a major fibrinolytic enzyme from Bacillus amyloliquefaciens MJ5-41 isolated from Meju
Jo HD, et al.
Journal of microbiology and biotechnology, 21(11), 1166-1173 (2011)
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Product Information Sheet - T6140

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