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T6260

Sodium taurochenodeoxycholate

Name: Sodium taurochenodeoxycholate
Brand: SIGMA

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Synonym(s):

2-([3α,7α-Dihydroxy-24-oxo-5β-cholan-24-yl]amino)ethanesulfonic acid sodium salt, 3α,7α-Dihydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide sodium salt, Taurochenodeoxycholic acid sodium salt

Empirical Formula (Hill Notation):

C₂₆H₄₄NNaO₆S

CAS Number:

6009-98-9

Molecular Weight:

521.69

Beilstein:

3901205

MDL number:

MFCD00036745

PubChem Substance ID:

24900362

NACRES:

NA.25

description

anionic

Assay

≥95.0% (TLC)

form

powder

mol wt

521.69 g/mol

CMC

HLB

20.1

functional group

sulfonic acid

shipped in

ambient

storage temp.

room temp

SMILES string

[H][C@@]12[C@]([C@](CC[C@@H](O)C3)(C)[C@]3([H])C[C@H]2O)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCC(NCCS(=O)([O-])=O)=O.[Na+]

InChI

1S/C26H45NO6S.Na/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29;/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33);/q;+1/p-1/t16-,17+,18-,19-,20+,21+,22-,24?,25+,26-;/m1./s1

InChI key

IYPNVUSIMGAJFC-ULWOGUKGSA-M

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Related Categories

Detergents - Anionic, Cationic, Zwitterionic, Anti-foaming

General description

An ionic detergent used for solubilizing lipids and proteins.

Sodium taurochenodeoxycholate is a bile acid that can be used as an anionic detergent.

Application

Sodium taurochenodeoxycholate has been used in a study to assess whether pancreatic β-cells contribute to BA-dependent regulation of glucose. It has also been used in a study to investigate short-term feedback regulation of sodium taurocholate cotransporting polypeptide (Ntcp) by bile salts in vivo.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Tauroursodeoxycholic acid affects PPARγ and TLR4 in Steatotic liver transplantation.

M B Jiménez-Castro et al.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 12(12), 3257-3271 (2012-09-22)

Numerous steatotic livers are discarded for transplantation because of their poor tolerance to ischemia-reperfusion (I/R). We examined whether tauroursodeoxycholic acid (TUDCA), a known inhibitor of endoplasmic reticulum (ER) stress, protects steatotic and nonsteatotic liver grafts preserved during 6 h in

ER stress in the brain subfornical organ mediates angiotensin-dependent hypertension.

Colin N Young et al.

The Journal of clinical investigation, 122(11), 3960-3964 (2012-10-16)

Although endoplasmic reticulum (ER) stress is a pathologic mechanism in a variety of chronic diseases, it is unclear what role it plays in chronic hypertension (HTN). Dysregulation of brain mechanisms controlling arterial pressure is strongly implicated in HTN, particularly in

Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue.

Noritaka Kawasaki et al.

Scientific reports, 2, 799-799 (2012-11-15)

Adipose tissue plays a central role in maintaining metabolic homeostasis under normal conditions. Metabolic diseases such as obesity and type 2 diabetes are often accompanied by chronic inflammation and adipose tissue dysfunction. In this study, we observed that endoplasmic reticulum

Small intestinal taurochenodeoxycholic acid-FXR axis alters local nutrient-sensing glucoregulatory pathways in rats.

T M Zaved Waise et al.

Molecular metabolism, 44, 101132-101132 (2020-12-03)

The mechanism of nutrient sensing in the upper small intestine (USI) and ileum that regulates glucose homeostasis remains elusive. Short-term high-fat (HF) feeding increases taurochenodeoxycholic acid (TCDCA; an agonist of farnesoid X receptor (FXR)) in the USI and ileum of

Sterol metabolism studies in the rat. Effects of primary bile acids (sodium taurochenodeoxycholate and sodium taurocholate) on sterol metabolism.

B I Cohen et al.

Journal of lipid research, 18(2), 223-231 (1977-03-01)

Sterol metabolism studies using a combination of isotopic and chromatographic procedures were carried out in rats fed either a low-cholesterol stock diet or a stock diet containing 0.1% cholesterol. The primary bile acids, sodium taurochenodeoxycholate and sodium taurocholate, were added

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