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T6394

Timolol maleate salt

Name: Timolol maleate salt
Brand: SIGMA

≥98% (TLC), β-adrenoceptor antagonist, powder

Synonym(s):

S-(−)-1-(t-Butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol maleate salt, Timolol hydrogen maleate

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₂₄N₄O₃S · C₄H₄O₄

CAS Number:

26921-17-5

Molecular Weight:

432.49

NACRES:

NA.77

PubChem Substance ID:

24277810

UNSPSC Code:

12352200

EC Number:

248-111-5

MDL number:

MFCD00058356

Assay:

≥98% (TLC)

Form:

powder

Quality level:

200

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Product Name

Timolol maleate salt, ≥98% (TLC), powder

Quality Level

200

assay

≥98% (TLC)

form

powder

optical activity

[α]25/D -5.4°, c = 4.9 in 1 M HCl(lit.)

color

white to off-white

mp

202-203 °C (lit.)

solubility

H₂O: soluble, ethanol: soluble

ε (extinction coefficient)

8,700 at 294 nm at 1 M

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

SMILES string

[H]\C(=C(/[H])C(O)=O)C(O)=O.CC(C)(C)NC[C@H](O)COc1nsnc1N2CCOCC2

InChI

1S/C13H24N4O3S.C4H4O4/c1-13(2,3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17;5-3(6)1-2-4(7)8/h10,14,18H,4-9H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t10-;/m0./s1

InChI key

WLRMANUAADYWEA-NWASOUNVSA-N

Gene Information

human ... ADRB1(153), ADRB2(154), ADRB3(155)

Related Categories

Bioactive Small Molecules

Application

Timolol maleate has been used as an adrenergic β-blocker for evaluating cardiovascular functions in mice⁵. It has also been used for evaluating the uptake of ⁸⁶Rb⁺ in rat cardiomyocytes⁶.

Biochem/physiol Actions

Timolol maleate is a class II anti-arrhythmic agent that functions as a non-selective β-adrenoceptor antagonist, a vasodilator and an anti-glaucoma agent. Studies have reported that timolol maleate can be used for the treatment of infantile hemangioma (IH)⁷.

Features and Benefits

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Timolol maleate is soluble in ethanol and water.

pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302,H361

pcodes

P201 - P301 + P312 + P330 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

监管及禁止进口产品

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RCT of timolol maleate gel for superficial infantile hemangiomas in 5- to 24-week-olds.

Hsien Chan et al.

Pediatrics, 131(6), e1739-e1747 (2013-05-08)

Timolol maleate 0.5% gel is a safe and effective medication for treating superficial infantile hemangiomas (IHs) in infants with a median age of 9 weeks. Forty-one infants who had superficial IHs without ulceration and not near mucosal surfaces were recruited

Development of O/W nanoemulsions for ophthalmic administration of timolol.

M Gallarate et al.

International journal of pharmaceutics, 440(2), 126-134 (2012-10-20)

After an initial screening of ingredients and production methods, nanoemulsions for ocular administration of timolol containing the drug as maleate (TM) or as ion-pair with AOT (TM/AOT) were prepared. The physico-chemical characterization of nanoemulsions, regarding mean diameter, pH, zeta potential

Glaucoma therapy by extended release of timolol from nanoparticle loaded silicone-hydrogel contact lenses.

Hyun Jung Jung et al.

Journal of controlled release : official journal of the Controlled Release Society, 165(1), 82-89 (2012-11-06)

Glaucoma is the second major cause of blindness in the world after cataract. Glaucoma management through eye drops that reduce the intraocular pressure (IOP) has major deficiencies including low patient compliance and low bioavailability. Extended wear contact lenses that deliver

Improved isolation of cardiomyocytes by trypsination in addition to collagenase treatment.

H Viko et al.

Pharmacology & toxicology, 76(1), 68-71 (1995-01-01)

The present study was undertaken to develop an improved and stabilized method for isolating cardiomyocytes from perfused rat heart. Different lots of the commercial collagenases used for isolating cardiomyocytes give variable results both with respect to the total cell yield

Retinal oximetry.

Sveinn Hakon Hardarson

Acta ophthalmologica, 91 Thesis 2, 1-47 (2013-03-09)

ABSTRACT.: Malfunction of retinal blood flow or oxygenation is believed to be involved in various diseases. Among them are retinal vessel occlusions, diabetic retinopathy and glaucoma. Reliable, non-invasive technology for retinal oxygen measurements has been scarce and most of the

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Global Trade Item Number

SKU	GTIN
T6394-1G	04061837371400
T6394-250MG	04061832094076
T6394-100MG	04061832094069

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