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Merck
CN

T6515

Cholecystokinin Fragment 30-33 Amide

≥95% (HPLC)

Synonym(s):

CCK-4, Gastrin Tetrapeptide, Tetragastrin, Trp-Met-Asp-Phe amide

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About This Item

Empirical Formula (Hill Notation):
C29H36N6O6S
CAS Number:
1947-37-1
Molecular Weight:
596.70
NACRES:
NA.32
PubChem Substance ID:
24900382
UNSPSC Code:
12352202
MDL number:
MFCD00076492

Key Documents

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Product Name

Cholecystokinin Fragment 30-33 Amide, ≥95% (HPLC)

InChI

1S/C29H36N6O6S/c1-42-12-11-22(33-27(39)20(30)14-18-16-32-21-10-6-5-9-19(18)21)28(40)35-24(15-25(36)37)29(41)34-23(26(31)38)13-17-7-3-2-4-8-17/h2-10,16,20,22-24,32H,11-15,30H2,1H3,(H2,31,38)(H,33,39)(H,34,41)(H,35,40)(H,36,37)/t20-,22-,23-,24-/m0/s1

SMILES string

CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O

InChI key

RGYLYUZOGHTBRF-BIHRQFPBSA-N

assay

≥95% (HPLC)

form

powder

mol wt

59670 g/mol

technique(s)

toxicology assay: suitable

solubility

DMF: 20 mg/mL, clear, colorless to yellow

suitability

suitable for molecular biology

UniProt accession no.

P06307
P30553

storage temp.

−20°C

Quality Level

200

Gene Information

human ... CCK(885)
rat ... Cckbr(25706)

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Application

Cholecystokinin Fragment 30-33 Amide can be used for inactivating the CCK8 antiserum. The product can also be used as an antigen utilized in absorption control for testing the specificity of antisera.Cholecystokinin Fragment 30-33 Amide has been used to induce anxiolytic- and antidepressant-like effects and study the role of neuropeptide Y, in mice.

Biochem/physiol Actions

Cholecystokinin Fragment 30-33 Amide also referred to as CCK-4 or Trp-Met-Asp-Phe amide is a peptide fragment derived from peptide hormone cholecystokinin. CCK-4 is a panicogenic agent that induces panic attacks in humans. This property of the compound can be used in scientific research for testing new anxiolytic drugs.CCK-4 acts selectively through CCK-B receptors and is recognized for its role in regulating emotional behaviors. Studies on CCK knock-down mice have indicated anxiolytic- and antidepressant-like effects.

General description

Research area: Neuroscience

Several biologically active fragments of the neuropeptide cholecystokinin (CCK) are present in the brain, where they interact with CCK-A and CCK-B receptors. Among these fragments, CCK-4 is notably abundant in the cortical and limbic brain structures. CCK-4, a bioactive form of cholecystokinin, is a peptide hormone that regulates food intake by binding to CCK receptors in the gut and brain.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

Cholecystokinin Fragment 30-33 Amide dissolves in Dimethylformamide at 20 mg/ml to yield a clear, colorless to yellow solution.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

监管及禁止进口产品
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Certificates of Analysis (COA)

Lot/Batch Number
BCCK2748
BCCF0358
BCCC0439
BCBT2449
BCBN4705V

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Thérèse Schunck et al.
Journal of psychopharmacology (Oxford, England), 25(1), 52-59 (2010-05-26)
Benzodiazepine effects on cholecystokinin tetrapeptide (CCK-4)-induced panic attack (PA) in humans are incompletely characterized, in particular on the neurofunctional level. This work explores the effects of lorazepam on brain activity and behavioral and physiological symptoms related to CCK-4-induced PA in
Andreas Ströhle et al.
Journal of psychiatric research, 43(12), 1013-1017 (2009-03-18)
Regular physical activity is anxiolytic in both healthy subjects and patients with panic disorder. In contrast, acute exercise may induce acute panic attacks or increase subjective anxiety in patients with panic disorder more than in other people. The effects of
Toyokazu Akimori et al.
Medical molecular morphology, 44(1), 7-14 (2011-03-23)
The function of brush cells is obscure, but recent cytochemical studies indicate that rat bile duct brush cells secrete NaHCO(3). The aim of this study was to determine the quantitative distribution of brush cells at 16 sites of the rat
A C Dieler et al.
Current pharmaceutical design, 14(33), 3492-3507 (2008-12-17)
Pharmacological magnetic resonance imaging (phMRI) is a method to study effects of psychopharmacological agents on neural activation. Changes of the blood oxygen level dependent (BOLD), the basis of functional MRI (fMRI), are typically obtained at relatively high sampling frequencies. This
Diana Koszycki et al.
Peptides, 35(1), 9-13 (2012-03-15)
Recent investigations suggest that genes that confer risk for panic disorder (PD) may moderate response to panicogenic agents in healthy volunteers. Given the potential role of the central cholecystokinin receptor (CCKBR) (CT) polymorphism alleles 26 and 27 in PD, the
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