T6568
Tyrphostin RG 13022
≥98%
Synonym(s):
2-(3,4′-Dimethoxyphenyl)-1-(3″-pyridinyl)acrylonitrile
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About This Item
Empirical Formula (Hill Notation):
C16H14N2O2
CAS Number:
Molecular Weight:
266.29
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
assay
≥98%
form
solid
potency
IC50 (3 micromolar for inhibition of EGF-receptor.)
mp
114-115 °C
solubility
DMSO or ethanol: soluble
storage temp.
2-8°C
SMILES string
COc1ccc(cc1OC)\C=C(\C#N)c2cccnc2
InChI
1S/C16H14N2O2/c1-19-15-6-5-12(9-16(15)20-2)8-14(10-17)13-4-3-7-18-11-13/h3-9,11H,1-2H3
InChI key
DBGZNJVTHYFQJI-UHFFFAOYSA-N
Biochem/physiol Actions
Non-phenolic tyrphostin-class tyrosine kinase inhibitor.
Preparation Note
Tyrphostin RG 13022 is known to suppress EGF-induced cancer cell proliferation under in vitro conditions and can also inhibit the growth of tumors in nude mice.
Tyrphostin RG 13022 is soluble in DMSO and ethanol.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| T6568-1MG | 04061826133248 |
| T6568-5MG | 04061832452647 |