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T7004

Sigma-Aldrich

Thymidine 5′-monophosphate disodium salt hydrate

≥99%

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Synonym(s):
5′-Thymidylic acid disodium salt, TMP, dTMP
Empirical Formula (Hill Notation):
C10H13N2Na2O8P · xH2O
CAS Number:
33430-62-5
Molecular Weight:
366.17 (anhydrous basis)
Beilstein:
4086927
EC Number:
251-518-0
MDL number:
MFCD09039259
PubChem Substance ID:
329826857

Assay

≥99%

storage temp.

−20°C

SMILES string

O.[Na+].[Na+].CC1=CN([C@H]2C[C@H](O)[C@@H](COP([O-])([O-])=O)O2)C(=O)NC1=O

InChI

1S/C10H15N2O8P.2Na.H2O/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18;;;/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18);;;1H2/q;2*+1;/p-2/t6-,7+,8+;;;/m0.../s1

InChI key

KCOPAVKVHIWPKB-SPSULGLQSA-L

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General description

Thymidine 5′-monophosphate de novo synthesis from deoxyuridine monophosphate (dUMP) is catalyzed by the enzyme thymidylate synthase.

Application

Thymidine 5′-monophosphate disodium salt hydrate has been used as a standard for the quantification of metabolites from plasma and tumor interstitial fluid using liquid chromatography-mass spectrometry analysis (LC/MS). It has also been used as a single deoxy-mononucleotide to test its effect on the cell growth of human malignant intestinal CaCo-2 cells and normal rat intestinal cell line IEC-6 cells.
Thymidine 5′-monophosphate disodium salt hydrate has been used as a standard solution.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Isolation and Quantification of Metabolite Levels in Murine Tumor Interstitial Fluid by LC/MS
Sullivan MR, et al.
Bio-protocol, 9(22) (9)
Medical Biochemistry null
Tiina Virtanen et al.
Scientific reports, 10(1), 3427-3427 (2020-02-27)
Membrane fouling is the major factor limiting the wider applicability of the membrane-based technologies in water treatment and in separation and purification processes of biorefineries, pulp and paper industry, food industry and other sectors. Endeavors to prevent and minimize fouling
Wenruo Bai et al.
IEEE/ACM transactions on computational biology and bioinformatics, 16(4), 1168-1181 (2018-07-12)
Identification of spectra produced by a shotgun proteomics mass spectrometry experiment is commonly performed by searching the observed spectra against a peptide database. The heart of this search procedure is a score function that evaluates the quality of a hypothesized
Koji Takada et al.
ACS applied materials & interfaces, 11(39), 35770-35776 (2019-09-10)
Concentrated electrolytes of LiN(SO2F)2 (LiFSA) and organic phosphates (e.g., trimethyl phosphate, TMP) are receiving intense attention for safe and long-lasting lithium-ion batteries, because of their nonflammable character and unusual passivation ability toward negative electrodes. However, their high viscosity and low
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