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Merck
CN

T7068

Sigma-Aldrich

Thymeleatoxin

99%, solid

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About This Item

Empirical Formula (Hill Notation):
C36H36O10
CAS Number:
94482-56-1
Molecular Weight:
628.67
MDL number:
MFCD00211206
UNSPSC Code:
12352200

Key Documents

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Assay

99%

form

solid

color

white

solubility

DMSO: soluble
H2O: insoluble
ethanol: soluble

storage temp.

−20°C

InChI

1S/C36H36O10/c1-19(2)34-28(42-25(38)16-15-22-11-7-5-8-12-22)21(4)35-24-17-20(3)27(39)33(24,41)31(40)32(18-37)29(43-32)26(35)30(34)44-36(45-34,46-35)23-13-9-6-10-14-23/h5-17,21,24,26,28-31,37,40-41H,1,18H2,2-4H3/b16-15+/t21-,24-,26+,28-,29+,30-,31-,32+,33-,34+,35-,36?/m1/s1

InChI key

OTTFLYUONKAFGT-WOYWLKGSSA-N

Biochem/physiol Actions

Selective activator of PKC isotypes α, β1 and γ

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
051K4700

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Scott A Barman et al.
American journal of physiology. Lung cellular and molecular physiology, 286(1), L149-L155 (2003-09-30)
Signaling mechanisms that elevate cyclic AMP (cAMP) activate large-conductance, calcium- and voltage-activated potassium (BKCa) channels in pulmonary vascular smooth muscle and cause pulmonary vasodilatation. BKCa channel modulation is important in the regulation of pulmonary arterial pressure, and inhibition (closing) of
Youn Ri Lee et al.
Journal of pharmacological sciences, 100(2), 119-125 (2006-02-14)
Vascular smooth muscle contraction is mediated by activation of extracellular signal-regulated kinase (ERK) 1/2, an isoform of mitogen-activated protein kinase (MAPK). However, the role of stress-activated protein kinase/c-Jun N-terminal kinase (JNK) in vascular smooth muscle contraction has not been defined.
Dierk Thomas et al.
Cardiovascular research, 59(1), 14-26 (2003-06-28)
Patients with HERG-associated long QT syndrome typically develop tachyarrhythmias during physical or emotional stress. Previous studies have revealed that activation of the beta-adrenergic system and consecutive elevation of the intracellular cAMP concentration regulate HERG channels via protein kinase A-mediated phosphorylation
Inês E Baldeiras et al.
Biological research, 39(3), 531-539 (2006-11-16)
Thymeleatoxin (TMX), an activator of Ca2+-sensitive protein kinase C (cPKC) isoforms, was used to assess the PKC isoform specificity of cholinergic potentiation of glucose (11 mM)-induced pulsatile 5-HT/insulin release (PIR) from single mouse pancreatic islets. TMX (100 nM) and carbachol
Bokyung Kim et al.
British journal of pharmacology, 139(2), 408-414 (2003-05-29)
1 Phorbol ester decreases muscle tension in the rat myometrium, and the effect is more potent in late-pregnant myometrium than in nonpregnant myometrium. In the present study, we have examined the contribution of protein kinase C (PKC) isoforms to the
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