T7068
Thymeleatoxin
99%, solid
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About This Item
Empirical Formula (Hill Notation):
C36H36O10
CAS Number:
Molecular Weight:
628.67
UNSPSC Code:
12352200
MDL number:
assay
99%
form
solid
color
white
solubility
DMSO: soluble, H2O: insoluble, ethanol: soluble
storage temp.
−20°C
InChI
1S/C36H36O10/c1-19(2)34-28(42-25(38)16-15-22-11-7-5-8-12-22)21(4)35-24-17-20(3)27(39)33(24,41)31(40)32(18-37)29(43-32)26(35)30(34)44-36(45-34,46-35)23-13-9-6-10-14-23/h5-17,21,24,26,28-31,37,40-41H,1,18H2,2-4H3/b16-15+/t21-,24-,26+,28-,29+,30-,31-,32+,33-,34+,35-,36?/m1/s1
InChI key
OTTFLYUONKAFGT-WOYWLKGSSA-N
Biochem/physiol Actions
Selective activator of PKC isotypes α, β1 and γ
Regulatory Information
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Related Content
Inês E Baldeiras et al.
Biological research, 39(3), 531-539 (2006-11-16)
Thymeleatoxin (TMX), an activator of Ca2+-sensitive protein kinase C (cPKC) isoforms, was used to assess the PKC isoform specificity of cholinergic potentiation of glucose (11 mM)-induced pulsatile 5-HT/insulin release (PIR) from single mouse pancreatic islets. TMX (100 nM) and carbachol
Bokyung Kim et al.
British journal of pharmacology, 139(2), 408-414 (2003-05-29)
1 Phorbol ester decreases muscle tension in the rat myometrium, and the effect is more potent in late-pregnant myometrium than in nonpregnant myometrium. In the present study, we have examined the contribution of protein kinase C (PKC) isoforms to the
Ann-Kathrin Rahm et al.
British journal of pharmacology, 166(2), 764-773 (2011-12-16)
Two-pore-domain K(+) channels (K(2P) ) mediate K(+) background currents that modulate the membrane potential of excitable cells. K(2P) 18.1 (TWIK-related spinal cord K(+) channel) provides hyperpolarizing background currents in neurons. Recently, a dominant-negative loss-of-function mutation in K(2P) 18.1 has been