T7068
Thymeleatoxin
99%, solid
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About This Item
Empirical Formula (Hill Notation):
C36H36O10
CAS Number:
Molecular Weight:
628.67
UNSPSC Code:
12352200
MDL number:
Product Name
Thymeleatoxin, 99%, solid
InChI
1S/C36H36O10/c1-19(2)34-28(42-25(38)16-15-22-11-7-5-8-12-22)21(4)35-24-17-20(3)27(39)33(24,41)31(40)32(18-37)29(43-32)26(35)30(34)44-36(45-34,46-35)23-13-9-6-10-14-23/h5-17,21,24,26,28-31,37,40-41H,1,18H2,2-4H3/b16-15+/t21-,24-,26+,28-,29+,30-,31-,32+,33-,34+,35-,36?/m1/s1
InChI key
OTTFLYUONKAFGT-WOYWLKGSSA-N
assay
99%
form
solid
color
white
solubility
DMSO: soluble
H2O: insoluble
ethanol: soluble
storage temp.
−20°C
Biochem/physiol Actions
Selective activator of PKC isotypes α, β1 and γ
Regulatory Information
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Ann-Kathrin Rahm et al.
British journal of pharmacology, 166(2), 764-773 (2011-12-16)
Two-pore-domain K(+) channels (K(2P) ) mediate K(+) background currents that modulate the membrane potential of excitable cells. K(2P) 18.1 (TWIK-related spinal cord K(+) channel) provides hyperpolarizing background currents in neurons. Recently, a dominant-negative loss-of-function mutation in K(2P) 18.1 has been
M G Kazanietz et al.
Molecular pharmacology, 44(2), 298-307 (1993-08-01)
Analysis of [3H]phorbol-12,13-dibutyrate (PDBu) binding was performed with protein kinase C (PKC)-alpha, -beta 1, -gamma, -delta, -epsilon, -eta, and -zeta produced in Sf9 insect cells using the baculovirus expression system. With the exception of PKC-zeta, all of the PKC isozymes
Jerzy Bełtowski et al.
Acta biochimica Polonica, 51(3), 757-772 (2004-09-28)
We examined the role of protein kinase C (PKC) in the regulation of Na+,K+- ATPase activity in the renal cortex. Male Wistar rats were anaesthetized and the investigated reagents were infused into the abdominal aorta proximally to the renal arteries.
Grant A Ramm et al.
Digestive diseases and sciences, 48(4), 790-796 (2003-05-14)
Protein kinase C (PKC) may play a role in the intracellular signaling pathways responsible for transforming hepatic stellate cells into myofibroblasts. This study examined the effects of inhibitors and activators of PKC on hepatic stellate cell activation. Stellate cells isolated
S Husain et al.
Biochimica et biophysica acta, 1392(1), 127-144 (1998-06-24)
We have investigated the role and mechanism of protein kinase C (PKC) isoforms in endothelin-1 (ET-1)-induced arachidonic acid (AA) release in cat iris sphincter smooth muscle (CISM) cells. ET-1 increased AA release in a concentration (EC50=8 nM) and time-dependent (t1/2=1.2
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