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Merck
CN

T7165

Tyrphostin 23

≥98%

Synonym(s):

(3,4-Dihydroxybenzylidene)malononitrile, RG-50810

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About This Item

Empirical Formula (Hill Notation):
C10H6N2O2
CAS Number:
118409-57-7
Molecular Weight:
186.17
NACRES:
NA.77
PubChem Substance ID:
24278041
UNSPSC Code:
12352200
MDL number:
MFCD00133899
Assay:
≥98%
Form:
powder
Quality level:
100

Key Documents

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Product Name

Tyrphostin 23, ≥98%

InChI

1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H

SMILES string

Oc1ccc(cc1O)\C=C(\C#N)C#N

InChI key

VTJXFTPMFYAJJU-UHFFFAOYSA-N

biological source

synthetic (organic)

assay

≥98%

form

powder

potency

35 μM IC50

solubility

DMSO: soluble 50 mg/mL, clear, yellow to brownish-yellow

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... CDK2(1017)

Related Categories

Application

Tyrphostin 23 can be used as a tyrosine kinase inhibitor for studying rat ghrelin-induced MAPK stimulation in GH3 cells. Tyrphostin 23 has also been used to analyze its effects on secretoneurin (SN)-induced chemotaxis of neutrophils.

Biochem/physiol Actions

Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ9317
MKCQ1112
MKCP4881
MKCF7678
MKCD6227

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Janusz Ligęza et al.
Acta biochimica Polonica, 58(3), 391-396 (2011-09-03)
Autocrine growth factors produced by epithelial cells mediate the development and proliferation of neoplastic human prostate tissue. Various approaches have been used to down-regulate neoplastic growth of prostate cancer using natural flavonoids, soluble receptors, pseudo-ligands, monoclonal antibodies and tyrosine kinase
E Heim
Zeitschrift fur Psychosomatische Medizin und Psychoanalyse, 38(3), 207-226 (1992-01-01)
Stressors and health risks in medical professions are still largely ignored. A survey on different studies in nurses, students, doctors and dentists by this author is compared to results of other authors. Special attention is given to role-strain and health
Masaru Fujimoto et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(13), 6094-6099 (2010-03-17)
Endocytosis performs a wide range of functions in animals and plants. Clathrin-coated vesicle (CCV) formation is an initial step of endocytosis, and in animal cells is largely achieved by dynamins. However, little is known of its molecular mechanisms in plant
Nathalie Leborgne-Castel et al.
Plant physiology, 146(3), 1255-1266 (2008-01-11)
The plant defense elicitor cryptogein triggers well-known biochemical events of early signal transduction at the plasma membrane of tobacco (Nicotiana tabacum) cells, but microscopic observations of cell responses related to these early events were lacking. We determined that internalization of
Sheung Kwan Lam et al.
The Plant journal : for cell and molecular biology, 60(5), 865-881 (2009-08-28)
Brefeldin A (BFA) is a useful tool for studying protein trafficking and identifying organelles in the plant secretory and endocytic pathways. At low concentrations (5-10 microg ml(-1)), BFA caused both the Golgi apparatus and trans-Golgi network (TGN), an early endosome
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Product Information Sheet - T7165

Product Information Sheet

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