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Merck
CN

T7515

Sodium taurolithocholate

Synonym(s):

3α-Hydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide, Taurolithocholic acid sodium salt

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About This Item

Linear Formula:
C26H44NO5SNa
CAS Number:
6042-32-6
Molecular Weight:
505.69
UNSPSC Code:
12161900
PubChem Substance ID:
24900457
NACRES:
NA.25

Key Documents

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SMILES string

C[C@H](CCC(NCCS(=O)(O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C.[Na]

InChI

1S/C26H45NO5S.Na.H/c1-17(4-9-24(29)27-14-15-33(30,31)32)21-7-8-22-20-6-5-18-16-19(28)10-12-25(18,2)23(20)11-13-26(21,22)3;;/h17-23,28H,4-16H2,1-3H3,(H,27,29)(H,30,31,32);;/t17-,18-,19-,20+,21-,22+,23+,25+,26-;;/m1../s1

InChI key

CMXYYIRKQPXCIE-RLHFEMFKSA-N

description

anionic

assay

≥97.0% (TLC)

mol wt

505.69 g/mol

application(s)

detection

Quality Level

200

Related Categories

Application

Sodium taurolithocholate has been used in a study to assess factors controlling the gastrointestinal adsorption of petroleum hydrocarbon residues. It has also been used in a study to investigate the decrease in activity of Na+, K+-adenosinetriphosphatase (Na+, K+-ATPase) in rats where cholestasis had been induced.

General description

Sodium taurolithocholate is a bile salt with detergent qualities that give it the ability to solubilize insoluble lipids.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000373029
0000334511
0000310778
0000334511
0000310778

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Gerald U Denk et al.
Hepatology (Baltimore, Md.), 52(5), 1758-1768 (2010-11-03)
NorUDCA (24-norursodeoxycholic acid), the C₂₃-homolog of ursodeoxycholic acid (UDCA), showed remarkable therapeutic effects in cholestatic Mdr2 (Abcb4) (multidrug resistance protein 2/ATP-binding cassette b4) knockout mice with sclerosing/fibrosing cholangitis. In contrast to UDCA, norUDCA is inefficiently conjugated in human and rodent
David M Booth et al.
Gastroenterology, 140(7), 2116-2125 (2011-03-01)
Oxidative stress is implicated in the pathogenesis of pancreatitis, but clinical trials of antioxidants have produced conflicting results. We examined the role of intracellular reactive oxygen species (ROS) in pancreatic acinar cell injury. Freshly isolated murine and human pancreatic acinar
J Reichen et al.
Experientia, 35(9), 1186-1188 (1979-09-15)
Na +, K + -adenosinetriphosphatase (Na +, K + -ATPase) activity was decreased in liver plasma membranes from rats in which cholestasis had been induced by i.v. administration of sodium taurolithocholate (5 mumoles/100 g b. wt). Incubation of liver plasma
Which way to die: the regulation of acinar cell death in pancreatitis by mitochondria, calcium, and reactive oxygen species.
Anna S Gukovskaya et al.
Gastroenterology, 140(7), 1876-1880 (2011-04-29)
Kjell B Døving et al.
The Journal of experimental biology, 214(Pt 1), 80-87 (2010-12-15)
In the present study, we exposed the olfactory epithelia of crucian carp, Carassius carassius, and brown trout, Salmo trutta, to dextran coupled with Alexa dyes together with odorants. Dye uptake was severely reduced after pre-exposure to nocodazole, an inhibitor of
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