T7665
Tyrphostin 51
≥98%
Synonym(s):
2-Amino-1,1,3-tricyano-4-(3′,4′,5′-trihydroxyphenyl)butadiene
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About This Item
Empirical Formula (Hill Notation):
C13H8N4O3
CAS Number:
Molecular Weight:
268.23
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98%
Form:
powder
biological source
synthetic (organic)
Quality Segment
assay
≥98%
form
powder
potency
0.8 μM IC50
solubility
DMSO: soluble 5 mg of Tyrphostin 51 in 0.1 ml of solvent, clear, orange to red
storage temp.
2-8°C
SMILES string
NC(\C(=C\c1cc(O)c(O)c(O)c1)C#N)=C(/C#N)C#N
InChI
1S/C13H8N4O3/c14-4-8(12(17)9(5-15)6-16)1-7-2-10(18)13(20)11(19)3-7/h1-3,18-20H,17H2/b8-1+
InChI key
JKNOYWVMHPMBEL-UNXLUWIOSA-N
Gene Information
human ... CDK2(1017), EGFR(1956)
Application
Tyrphostin 51 has been used to study the inhibition of rat hepatic leptin 1.
Biochem/physiol Actions
EGFR tyrosine kinase inhibitor.
Tyrphostin 51 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Preparation Note
5 mg of Tyrphostin 51 is soluble in 0.1 ml of DMSO and yields a clear, orange to red solution.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Product Information Sheet
Global Trade Item Number
| SKU | GTIN |
|---|---|
| T7665-5MG | 04061837378539 |
| T7665-25MG | 04061832964263 |