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Merck
CN

T7687

Anti-Tissue Inhibitor of Metalloproteinase-3, First Loop antibody produced in rabbit

~1 mg/mL, buffered aqueous glycerol solution, affinity isolated antibody

Synonym(s):

Anti-TIMP-3

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD01634335

Key Documents

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Product Name

Anti-Tissue Inhibitor of Metalloproteinase-3, First Loop antibody produced in rabbit, ~1 mg/mL, buffered aqueous glycerol solution, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

species reactivity

human

concentration

~1 mg/mL

technique(s)

western blot: 1:1,000 using a whole cell extract from human fibroblasts (M 3303)

UniProt accession no.

P35625

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... TIMP3(7078)

Physical form

Solution in phosphate buffered saline, pH 7.4, containing 50% glycerol and 0.05% sodium azide.

Biochem/physiol Actions

By immunoblotting against the reduced protein, the antibody reacts with bands at ~24 kDa and 30 kDa (unglycosylated and glycosylated, respectively). It also reacts with non-reduced TIMP-3.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

synthetic peptide corresponding to the first loop of human tissue inhibitor of metalloproteinase-3.

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pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H319,H334

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
0000282898
0000282898
SLBV5365
SLBV5363
SLBK3629V

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Z Saihan et al.
Molecular vision, 15, 1218-1230 (2009-06-19)
To determine the phenotypic and biochemical characteristics of the p.E139K missense variant in tissue inhibitor of metalloproteinase 3 (TIMP3) associated with Sorsby fundus dystrophy (SFD). The coding regions and adjacent intronic sequence of TIMP3 were amplified by polymerase chain reaction
Sarah Naessens et al.
Human mutation, 40(5), 539-551 (2019-01-23)
Sorsby fundus dystrophy (SFD) is a macular degeneration caused by mutations in TIMP3, the majority of which introduce a novel cysteine. However, the exact molecular mechanisms underlying SFD remain unknown. We aimed to provide novel insights into the functional consequences

Related Content

Data Sheet - T7687

Instructions

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