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T7697

I-OMe-Tyrphostin AG 538

solid

Synonym(s):

α-Cyano-(3-methoxy-4-hydroxy-5-iodocinnamoyl)-(3′,4′-dihydroxyphenyl)ketone, I-OMe-AG 538

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About This Item

Empirical Formula (Hill Notation):
C17H12INO5
CAS Number:
1094048-77-7
Molecular Weight:
437.19
NACRES:
NA.77
PubChem Substance ID:
24278758
UNSPSC Code:
12352203
MDL number:
MFCD03453582
Form:
solid
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form

solid

Quality Segment

100

solubility

DMSO: 50 mg/mL

storage temp.

−20°C

SMILES string

COc1cc(cc(I)c1O)\C=C(/C#N)C(=O)c2ccc(O)c(O)c2

InChI

1S/C17H12INO5/c1-24-15-6-9(5-12(18)17(15)23)4-11(8-19)16(22)10-2-3-13(20)14(21)7-10/h2-7,20-21,23H,1H3/b11-4+

InChI key

HSRMHXWCTRFVHK-NYYWCZLTSA-N

Gene Information

human ... IGF1(3479), IGF1R(3480)

Application

I-OMe-Tyrphostin AG 538 has been used as a cell signaling inhibitor in PC-1 cell lines. It has also been used in high throughput screening assays for IGF1R inhibitors.

Biochem/physiol Actions

Insulin growth factor 1 (IGF-1) receptor protein tyrosine kinase inhibitor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Preparation Note

I-OMe-Tyrphostin AG 538 is soluble in DMSO at 50 mg/ml.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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