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T8325

TDZD-8

Name: TDZD-8
Brand: SIGMA

≥98% (HPLC), needles

Synonym(s):

4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₀N₂O₂S

CAS Number:

327036-89-5

Molecular Weight:

222.26

NACRES:

NA.77

PubChem Substance ID:

329826879

UNSPSC Code:

12352200

MDL number:

MFCD04973552

Assay:

≥98% (HPLC)

Form:

needles

Storage condition:

protect from light

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

needles

storage condition

protect from light

color

white

mp

63-64.4 °C

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

CN1SC(=O)N(Cc2ccccc2)C1=O

InChI

1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3

InChI key

JDSJDASOXWCHPN-UHFFFAOYSA-N

Description

Application

TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program. TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb.

Biochem/physiol Actions

TDZD-8 is a selective inhibitor of GSK-3, a thiadiazolidinone derivative, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 μM). It does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. TDZD-8 has been proposed to bind to the kinase site of GSK-3β.

TDZD-8 is a selective inhibitor of GSK-3.

Features and Benefits

This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

TDZD-8 is soluble in DMSO at a concentration that is greater than 10 mg/ml.

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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