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T8441

L-Threonine

Name: <SC>L</SC>-Threonine
Brand: SIGMA

99.0-101.0%, suitable for cell culture, BioXtra, non-animal source

Synonym(s):

(2S,3R)-2-Amino-3-hydroxybutyric acid

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About This Item

Linear Formula:

CH₃CH(OH)CH(NH₂)CO₂H

CAS Number:

72-19-5

Molecular Weight:

119.12

NACRES:

NA.26

PubChem Substance ID:

24900531

eCl@ss:

32160406

UNSPSC Code:

12352209

EC Number:

200-774-1

MDL number:

MFCD00064270

Beilstein/REAXYS Number:

1721646

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Product Name

L-Threonine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 99.0-101.0%

biological source

non-animal source

Quality Level

300

agency

USP/NF, meets EP testing specifications, meets JP testing specifications, meets USP testing specifications

product line

BioXtra

assay

99.0-101.0%

form

powder

quality

meets EP, JP, USP testing specifications

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white

mp

256 °C (dec.) (lit.)

solubility

H₂O: 1 g/10 mL, clear, colorless

application(s)

pharmaceutical (small molecule)

SMILES string

C[C@@H](O)[C@H](N)C(O)=O

InChI

1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1

InChI key

AYFVYJQAPQTCCC-GBXIJSLDSA-N

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Related Categories

Amino Acids – Building Blocks of Life Science

Biochemicals

Cell Culture Supplements & Reagents

High-Purity Biochemicals and Reagents

General description

L-Threonine is a naturally occurring amino acid belonging to the aspartate family of amino acids.

Application

L-Threonine has been used for the following :

To study the effect of heat on homoserine kinase activity
In Plackett–Burman analysis and then to study the effect of selected amino acids on monoclonal antibody production in CHO cells
As a substrate to determine the L-threonine dehydrogenase activity
To study the effect of L-Threonine on the growth rate of P. putida, to check for its tolerance towards L-Threonine

Biochem/physiol Actions

L-Threonine is considered to be an essential amino acid. L-Threonine is involved in the synthesis of mucin, a protein supporting intestinal function and integrity. L-Threonine is required for the performance of the immune system. It is also essential for O-linked glycosylation, protein phosphorylation and glycine synthesis.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Systems metabolic engineering of Escherichia coli for L?threonine production.

Lee HK, et al.

Molecular Systems Biology, 3(1), 149-149 (2007)

Regulation of L-Threonine Dehydrogenase in Somatic Cell Reprogramming

Chuanchun Han

Stem Cells, 31(5) (2013)

Homoserine Kinase from Escherichia coli K-12: Properties,
Inhibition by L-Threonine, and Regulation of Biosynthesis

J. THEZE

Journal of Bacteriology, 118(2), 577-581 (1974)

Use of a Plackett-Burman statistical design to determine the effect of selected amino acids on monoclonal antibody production in CHO cells.

Gonzalez-Leal IJ

Biotechnol. Progress, 27(6), 1709-1717 (2011)

Genome-wide identification of tolerance mechanisms toward p-coumaric acid in Pseudomonas putida

Patricia Calero

Biotechnology and Bioengineering, 115(3), 762-774 (2018)

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Global Trade Item Number

SKU	GTIN
T8441-10MG	04061837379246
T8441-1KG	04061837379253
T8441-100G	04061837379239
T8441-25G	04061835550326
T8441-10G	04061833352366

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