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About This Item
UNSPSC Code:
51111800
biological source
bovine pituitary glands
Quality Segment
form
lyophilized powder
mol wt
(α subunit ≈ 13–15 kDa
β subunit ≈ 15–17 kDa
Total ≈ 28–32 kDa)
purified by
chromatography
suitability
suitable for molecular biology
shipped in
wet ice
storage temp.
-10 to -25°C
target post-translational modification
disulfide bond
Gene Information
bovine ... CGA(280749), TSHB(281552)
General description
TSH is a heterodimeric glycoprotein hormone secreted by the anterior pituitary gland. It consists of a common α-subunit shared with other glycoprotein hormones (FSH, LH, and hCG) and a hormone-specific β-subunit that confers receptor specificity. Native bovine TSH is structurally conserved across mammalian species and exhibits biological activity through interaction with the thyroid-stimulating hormone receptor (TSHR). As a glycosylated protein, its biological activity and stability are influenced by its carbohydrate moieties.
Application
Thyroid stimulating hormone has been used in:
- Studies of thyroid function and regulation
- Cell-based assays involving TSH receptor activation
- Endocrine signaling and hormone response studies
- Assays evaluating thyroid hormone biosynthesis
Biochem/physiol Actions
TSH binds to the TSH receptor (TSHR) on thyroid follicular cells, activating cAMP-dependent signaling pathways that regulate thyroid hormone synthesis and secretion (T3 and T4). It plays a central role in maintaining metabolic homeostasis and regulating growth and development.
Physical form
Lyophilized from 10mM KPB (pH 8.0), 0.150M NaCl
Preparation Note
It is recommended that the powder be reconstituted in physiological saline (PH7.0)
Storage Class
11 - Combustible Solids
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