T9145
Thyroglobulin from bovine thyroid
(For Gel Filtration Chromatography)
Synonym(s):
Tg
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About This Item
Form:
powder
Biological source:
bovine thyroid
Mol wt:
~670 kDa
biological source
bovine thyroid
Quality Segment
form
powder
mol wt
~670 kDa
technique(s)
bioconjugation: suitable
UniProt accession no.
storage temp.
−20°C
Gene Information
cow ... TG(280706)
Application
Often used as a carrier protein for the production of antibodies. Its advantage is the large number of tyrosine residues that can be used for conjugation using the diazo reaction.
Thyroglobulin is used for antibody purification and characterization. Thyroglobulin has been used in studies assessing the monitoring of differentiated thyroid cancer as well as to develop an accurate diagnostic tool for patients with autoimmune thyroid diseases.
Biochem/physiol Actions
Iodine-containing protein that is stored in the thyroid gland. Converted into circulating thyroxines when the thyroid is stimulated by thyroid-stimulating hormone (TSH) from the pituitary. Because its expression is unique to the thyroid, it is a sensitive indicator of recurrence or metastasis of thyroid cancer that has been treated by thyroid ablation.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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