T9177
Tyrphostin AG 126
≥90%
Synonym(s):
(3-Hydroxy-4-nitrobenzylidene)malononitrile
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About This Item
Empirical Formula (Hill Notation):
C10H5N3O3
CAS Number:
Molecular Weight:
215.17
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
assay
≥90%
storage temp.
−20°C
SMILES string
Oc1cc(ccc1[N+]([O-])=O)\C=C(\C#N)C#N
Gene Information
human ... TNF(7124)
Application
Tyrphostin AG 126 has been used in LOPAC screening assays to identify histone deacetylase (HDAC) inhibitors.
Biochem/physiol Actions
Tyrphostin AG 126 is a tyrosine kinase inhibitor that is known to block the production of tumor necrosis factor-alpha (TNF-alpha) and nitric oxide in macrophages. Furthermore, studies have reported that AG 126 can reduce zymosan-induced multiple organ failure in rats, block the postoperative ileus development in mice, and also decrease colitis development in rats.
Storage Class
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Regulatory Information
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Hua Yuan et al.
American journal of physiology. Heart and circulatory physiology, 296(2), H470-H479 (2008-12-23)
Bacterial endotoxin lipopolysaccharide (LPS) is responsible for the multiorgan dysfunction that characterizes septic shock and is causal in the myocardial depression that is a common feature of endotoxemia in patients. In this setting the myocardial dysfunction appears to be due
Klemens Angstwurm et al.
Infection and immunity, 72(6), 3294-3298 (2004-05-25)
Bacterial meningitis is an acute inflammatory disease of the central nervous system with a mortality rate of up to 30%. Excessive stimulation of the host immune system by bacterial surface components contributes to this devastating outcome. In vitro studies have
Beverley A Moore et al.
American journal of physiology. Gastrointestinal and liver physiology, 286(2), G214-G224 (2003-09-27)
Manipulation of the bowel during abdominal surgery leads to a period of ileus, which is most severely manifested after procedures that directly involve the colon. Ileus is associated with the increased expression of proinflammatory cytokines and chemokines, a leukocytic infiltration
Jacob George et al.
Experimental and molecular pathology, 76(3), 234-241 (2004-05-06)
Experimental autoimmune myocarditis (EAM) in rats is a T-cell-mediated disorder; the involvement of TNF-alpha in this disorder has been demonstrated. EAM represents a model for human autoimmune myocarditis, a condition for which no optimal treatment is currently available. Tyrphostins AG-126
Yun Jeong Kim et al.
Neurochemical research, 35(4), 603-612 (2009-12-04)
The preventive effect of tyrosine kinase inhibitor AG126 against the 7-ketocholesterol toxicity was investigated in relation to the mitochondria-mediated cell death process. 7-Ketocholesterol induced the nuclear damage, the mitochondrial membrane permeability changes, the formation of reactive oxygen species and the
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