U2383
Ubiquitin Carrier Protein H3/CDC34 human
≥95% (SDS-PAGE), recombinant, expressed in E. coli overproducing strain
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About This Item
Form:
solution
Assay:
≥95% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli overproducing strain
Mol wt:
~32 kDa
biological source
human
Quality Segment
recombinant
expressed in E. coli overproducing strain
assay
≥95% (SDS-PAGE)
form
solution
mol wt
~32 kDa
application(s)
cell analysis
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... CDC34(997), UBE2N(7334)
Biochem/physiol Actions
Cdc34 is an essential gene for viability in yeast. Cdc34 mediates the transition from G1 to S-phase of the cell cycle by degrading the S-phase cyclin/CDK inhibitor, SIC1 in yeast and p27(KIP1) in human. Cdc34 is also known to interact with the Skp1/Cdc53/F-box (SCF) ubiquitin ligase subunits Cul1 to degrade the NF-κB inhibitor IκBα in a phosphorylation-dependent manner.
Infected cell protein 0 of herpes simplex virus 1 was shown to bind UbcH3 and induce its degradation by promoting its polyubiquination. This resulted in increased expression of an UbcH3-target gene cyclin D1 and aided in further viral infection.
Physical form
Solution in 50 mM HEPES, 200 mM NaCl, 1 mM TCEP (pH 7.5), and 10% glycerol.
Other Notes
Manufactured for Sigma by Boston Biochem. Inc.
Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| U2383-100UG | 04061838166432 |