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U4127

Urocortin human

Name: Urocortin human
Brand: SIGMA

≥85% (HPLC), powder

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About This Item

Empirical Formula (Hill Notation):

C₂₀₄H₃₃₇N₆₃O₆₄

CAS Number:

176591-49-4

Molecular Weight:

4696.24

UNSPSC Code:

12352200

NACRES:

NA.32

MDL number:

MFCD00802621

Form:

powder

Assay:

≥85% (HPLC)

Biological source:

human

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Properties

biological source

human

Quality Segment

200

assay

≥85% (HPLC)

form

powder

technique(s)

ligand binding assay: suitable

UniProt accession no.

P55089

storage temp.

−20°C

Gene Information

human ... UCN(7349)

Description

Application

Urocortin human can be used as a test compound for studying the impact of corticotropin-releasing factor (CRF) receptor agonist and antagonist on sleep-wake patterns in conscious rats by using radiotelemetry system.

Biochem/physiol Actions

Binds to CRF receptor types 1, 2α, and 2β.

Binds to CRF receptor types 1, 2α, and 2β; stimulates cAMP accumulation from cells transfected with these receptors. Acts in vitro to release ACTH from rat anterior pituitary cells.

Urocortin is a CRF-related neuropeptide having high affinity for CRF2 receptor possess appetite-suppressing effect. Urocortin along with corticotropin-releasing factor (CRF) binding protein (CRF-BP) enhances the free CRF levels in human brain by displacing hCRF from the binding protein.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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