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U4127

Urocortin human

≥85% (HPLC), powder

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About This Item

Empirical Formula (Hill Notation):
C204H337N63O64
CAS Number:
Molecular Weight:
4696.24
UNSPSC Code:
12352200
NACRES:
NA.32
MDL number:
Form:
powder
Assay:
≥85% (HPLC)
Biological source:
human
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biological source

human

Quality Segment

assay

≥85% (HPLC)

form

powder

technique(s)

ligand binding assay: suitable

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... UCN(7349)

Application

Urocortin human can be used as a test compound for studying the impact of corticotropin-releasing factor (CRF) receptor agonist and antagonist on sleep-wake patterns in conscious rats by using radiotelemetry system.

Biochem/physiol Actions

Urocortin is a CRF-related neuropeptide having high affinity for CRF2 receptor possess appetite-suppressing effect. Urocortin along with corticotropin-releasing factor (CRF) binding protein (CRF-BP) enhances the free CRF levels in human brain by displacing hCRF from the binding protein.
Binds to CRF receptor types 1, 2α, and 2β.
Binds to CRF receptor types 1, 2α, and 2β; stimulates cAMP accumulation from cells transfected with these receptors. Acts in vitro to release ACTH from rat anterior pituitary cells.


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



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