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U4500

Uridine 5′-diphosphogalactose disodium salt

Name: Uridine 5&#8242;-diphosphogalactose disodium salt
Brand: SIGMA

≥97.0%, from bovine milk, powder

Synonym(s):

UDP-Gal, UDP-galactose

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₂₂N₂Na₂O₁₇P₂

CAS Number:

137868-52-1

Molecular Weight:

610.27

UNSPSC Code:

41106305

PubChem Substance ID:

24900647

NACRES:

NA.51

MDL number:

MFCD00077895

Assay:

≥97.0%

Biological source:

bovine milk, rabbit muscle, yeast

Form:

powder

Solubility:

water: 50 mg/mL, clear, colorless

Storage temp.:

−20°C

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Product Name

Uridine 5′-diphosphogalactose disodium salt, ≥97.0%

Quality Level

200

biological source

bovine milk, rabbit muscle, yeast

assay

≥97.0%

form

powder

solubility

water: 50 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

[Na+].[Na+].OC[C@H]1O[C@@H](OP([O-])(=O)OP([O-])(=O)OC[C@H]2OC([C@H](O)[C@@H]2O)N3C=CC(=O)NC3=O)[C@H](O)[C@@H](O)[C@H]1O

InChI

1S/C15H24N2O17P2.2Na/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25;;/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25);;/q;2*+1/p-2/t5-,6-,8+,9-,10+,11-,12-,13?,14?;;/m1../s1

InChI key

PKJQEQVCYGYYMM-OUJOOSCPSA-L

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Related Categories

Biochemicals

Nucleosides and Nucleotides

General description

Uridine 5′-diphospho-α-D-galactose/UDP-Gal is a nucleotide sugar.

Application

Uridine 5′-diphosphogalactose disodium salt has been used as a component in galactosyltransferase labeling buffer to prelabel terminal N-acetylglucosamine (GlcNAc) on immunoglobulin chains. It has also been used as a component in Hyp O-galactosyltransferase (HPGT) assay.

Biochem/physiol Actions

Uridine 5′-diphospho-α-D-galactose/UDP-Gal can block BALB/3T12 cell development. In mammals, it is very essential for glycoconjugate biosynthesis.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

涉药品监管产品

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Enzymatic synthesis of UDP-galactose on a gram scale

Bulter T and Elling L

Journal of Molecular Catalysis. B, Enzymatic, 8(4-6), 281-284 (2000)

LC/MS-based Detection of Hydroxyproline O-galactosyltransferase Activity

Ogawa-Ohnishi M and Matsubayashi Y

Bio-protocol, 19(10), 4130-4140 (2016)

UDP-galactose inhibition of BALB/3T12-3 cell growth: Requirement for medium galactosyltransferase activity

Klohs W D, et al.

Experimental Cell Research, 141(2), 365-374 (1982)

High Resolution Structures of the Human ABO(H) Blood Group Enzymes in Complex with Donor Analogs Reveal That the Enzymes Utilize Multiple Donor Conformations to Bind Substrates in a Stepwise Manner.

Susannah M L Gagnon et al.

The Journal of biological chemistry, 290(45), 27040-27052 (2015-09-17)

Homologous glycosyltransferases α-(1→3)-N-acetylgalactosaminyltransferase (GTA) and α-(1→3)-galactosyltransferase (GTB) catalyze the final step in ABO(H) blood group A and B antigen synthesis through sugar transfer from activated donor to the H antigen acceptor. These enzymes have a GT-A fold type with characteristic

Cross-talks of glycosylphosphatidylinositol biosynthesis with glycosphingolipid biosynthesis and ER-associated degradation.

Yicheng Wang et al.

Nature communications, 11(1), 860-860 (2020-02-15)

Glycosylphosphatidylinositol (GPI)-anchored proteins and glycosphingolipids interact with each other in the mammalian plasma membranes, forming dynamic microdomains. How their interaction starts in the cells has been unclear. Here, based on a genome-wide CRISPR-Cas9 genetic screen for genes required for GPI

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Glycosyltransferases

Enzymatic glycosyltransferase specificity challenges the one enzyme-one linkage concept.

Glycosyltransferases: Tools for Synthesis and Modification of Glycans

Explore tools for glycosyltransferase synthesis and modification of glycans, such as glycosyltransferases and nucleotide sugar donors.

Analysis: Activated Nucleotide Sugars by LC-MS/MS

LC-MS/MS method quantifies similar polar nucleotide activated sugars using Supel™ Carbon LC column for simultaneous analysis.

Global Trade Item Number

SKU	GTIN
U4500-10MG	04061833008096
U4500-25MG	04061833008102
U4500-5MG	04061837409592
U4500-100MG	04061833008089

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