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U4625

Uridine 5′-diphosphoglucose disodium salt hydrate from Saccharomyces cerevisiae

≥98%, from Saccharomyces cerevisiae, powder

Synonym(s):

UDP-Glc hydrate, UDPG hydrate

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About This Item

Empirical Formula (Hill Notation):
C15H22N2Na2O17P2 · xH2O
CAS Number:
Molecular Weight:
610.27 (anhydrous basis)
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
MDL number:
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Product Name

Uridine 5′-diphosphoglucose disodium salt hydrate from Saccharomyces cerevisiae, ≥98%

storage temp.

−20°C

Quality Level

SMILES string

O.[Na+].[Na+].OC[C@H]1O[C@H](OP([O-])(=O)OP([O-])(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N3C=CC(=O)NC3=O)[C@H](O)[C@@H](O)[C@@H]1O

InChI key

SRHFBUUOPANXBG-WSIJJEQHSA-L

InChI

1S/C15H24N2O17P2.2Na.H2O/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25;;;/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25);;;1H2/q;2*+1;/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14-;;;/m1.../s1

biological source

Saccharomyces cerevisiae

assay

≥98%

form

powder

solubility

water: 50 mg/mL, clear, colorless

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Application

Uridine 5′-diphosphoglucose disodium salt hydrate from Saccharomyces cerevisiae has been used as a substrate
  • for the PpIRX10 enzyme activity from Arabidopsis thaliana
  • in radiometric assay of glycosyltransferases (GTs)
  • in uridine diphosphate glucose (UDP-Glc) 4-epimerase assay in Arabidopsis thaliana samples

Biochem/physiol Actions

Uridine diphosphate glucose (UDP-glucose) is an essential mediator of the cellular metabolic pathways. In yeast, the high levels of trehalose and glycogen favor increased levels of UDP-glucose.

General description

Uridine diphosphate glucose (UDP-glucose) is a glycogen precursor. The transfer of glucose from UDP-glucose to growing glycogen chain is catalyzed by the enzyme glycogen synthase. The enzyme uridine diphosphate galactose-4-epimerase catalyzes the formation of UDP-glucose from UDP-galactose.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品
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Distinct properties of the five UDP-D-glucose/UDP-D-galactose 4-epimerase isoforms of Arabidopsis thaliana
Barber C, et al.
The Journal of Biological Chemistry, 281(25), 17276-17285 (2006)
Fariborz Parandeh et al.
The Journal of biological chemistry, 295(45), 15245-15252 (2020-08-29)
Type-2 diabetes (T2D) is a global disease caused by the inability of pancreatic β-cells to secrete adequate insulin. However, the molecular mechanisms underlying the failure of β-cells to respond to glucose in T2D remains unknown. Here, we investigated the relative
Hypoglycemia as a Pathological Result in Medical Praxis
Type 1 Diabetes Complications (2011)
A quaternary mechanism enables the complex biological functions of octameric human UDP-glucose pyrophosphorylase, a key enzyme in cell metabolism
Fuhring J, et al.
Scientific Reports, 5, 9618-9618 (2015)
Unravelling evolutionary strategies of yeast for improving galactose utilization through integrated systems level analysis
Hong KK, et al.
Proceedings of the National Academy of Sciences of the USA, 108(29), 12179-12184 (2011)

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