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U5252

Uridine 5′-diphospho-N-acetylgalactosamine disodium salt

Name: Uridine 5&#8242;-diphospho-N-acetylgalactosamine disodium salt
Brand: SIGMA

≥97%, synthetic (organic), powder

Synonym(s):

(UDP)-GalNAc, UDP-GalNAc, UDP-N-acetylgalactosamine, Uridine[5′]diphospho[1](2-acetamino-2-deoxy-α-D-galactopyranose) disodium salt

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₂₅N₃Na₂O₁₇P₂

CAS Number:

108320-87-2

Molecular Weight:

651.32

NACRES:

NA.51

PubChem Substance ID:

24900653

UNSPSC Code:

41106305

MDL number:

MFCD00077894

Beilstein/REAXYS Number:

5375867

Assay:

≥97%

Biological source:

synthetic (organic)

Form:

powder

Solubility:

water: 50 mg/mL, clear, colorless

Storage temp.:

−20°C

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Product Name

Uridine 5′-diphospho-N-acetylgalactosamine disodium salt, ≥97%

biological source

synthetic (organic)

Quality Level

200

assay

≥97%

form

powder

solubility

water: 50 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

[Na+].[Na+].CC(=O)N[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1OP([O-])(=O)OP([O-])(=O)OC[C@H]2OC([C@H](O)[C@@H]2O)N3C=CC(=O)NC3=O

InChI

1S/C17H27N3O17P2.2Na/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28;;/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28);;/q;2*+1/p-2/t7-,8-,10-,11+,12-,13-,14-,15?,16?;;/m1../s1

InChI key

HXWKMJZFIJNGES-QCVFHWOISA-L

Related Categories

Biochemicals

Nucleosides and Nucleotides

General description

Uridine diphosphate (UDP)-GalNAc acts as a precursor in the biosynthesis of O-linked oligosaccharide. It also acts as a substrate for synthesis of chitin, a vital element of cell walls in fungi and of exoskeletons of arthropods and insects.

Application

Uridine 5′-diphospho-N-acetylgalactosamine disodium salt has been used as a substrate for polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-T).

wgk

WGK 3

Storage Class

11 - Combustible Solids

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Expression of UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase isozymes T1 and T2 in human colorectal cancer

Kohsaki T, et al.

Journal of Gastroenterology, 35(11), 840-848 (2000)

Ser and Thr acceptor preferences of the GalNAc-Ts vary among isoenzymes to modulate mucin-type O-glycosylation.

Earnest James Paul Daniel et al.

Glycobiology, 30(11), 910-922 (2020-04-19)

A family of polypeptide GalNAc-transferases (GalNAc-Ts) initiates mucin-type O-glycosylation, transferring GalNAc onto hydroxyl groups of Ser and Thr residues of target substrates. The 20 GalNAc-T isoenzymes in humans are classified into nine subfamilies according to sequence similarity. GalNAc-Ts select their

Epitope-mapping of the glycoprotein from Crimean-Congo hemorrhagic fever virus using a microarray approach.

Amanda Fritzen et al.

PLoS neglected tropical diseases, 12(7), e0006598-e0006598 (2018-07-10)

Crimean-Congo hemorrhagic fever virus (CCHFV) causes severe acute human disease with lethal outcome. The knowledge about the immune response for this human health threat is highly limited. In this study, we have screened the glycoprotein of CCHFV for novel linear

Enzymatic sialylation of IgA1 O-glycans: implications for studies of IgA nephropathy.

Kazuo Takahashi et al.

PloS one, 9(2), e99026-e99026 (2014-06-12)

Patients with IgA nephropathy (IgAN) have elevated circulating levels of IgA1 with some O-glycans consisting of galactose (Gal)-deficient N-acetylgalactosamine (GalNAc) with or without N-acetylneuraminic acid (NeuAc). We have analyzed O-glycosylation heterogeneity of naturally asialo-IgA1 (Ale) myeloma protein that mimics Gal-deficient

Prediction of functional modules based on comparative genome analysis and Gene Ontology application.

Hongwei Wu et al.

Nucleic acids research, 33(9), 2822-2837 (2005-05-20)

We present a computational method for the prediction of functional modules encoded in microbial genomes. In this work, we have also developed a formal measure to quantify the degree of consistency between the predicted and the known modules, and have

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Global Trade Item Number

SKU	GTIN
U5252-25MG	04061833008195
U5252-100MG	04061837409745
U5252-5MG	04061837409752

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