U6631
Urocortin rat
≥97% (HPLC), powder
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About This Item
Empirical Formula (Hill Notation):
C206H338N62O64
CAS Number:
Molecular Weight:
4707.26
UNSPSC Code:
12352200
NACRES:
NA.32
MDL number:
Form:
powder
Assay:
≥97% (HPLC)
Biological source:
rat
biological source
rat
Quality Segment
assay
≥97% (HPLC)
form
powder
technique(s)
western blot: suitable
solubility
1% acetic acid: >1 mg/mL, clear, colorless
UniProt accession no.
storage temp.
−20°C
Gene Information
rat ... Ucn(29151)
Application
Urocortin rat can be used for western blotting. The product can also be used for studying that whether CRF receptor type 2 (CRF2) and its high-affinity ligand, urocortin 1 (Ucn1) can mediate sex-specific cellular stress responses by using corticotropin-releasing factor receptor 2-deficient (Crhr2-/- ) and wild-type (WT) mice.
Biochem/physiol Actions
Urocortin is a CRF-related neuropeptide that binds to CRF receptor types 1α, 2α and 2β. It possesses appetite-suppressing effect. Urocortin along with corticotropin-releasing factor (CRF) binding protein (CRF-BP) enhances the free CRF levels in human brain by displacing hCRF from the binding protein.
Binds to CRF receptor types 1, 2α, and 2β.
Binds to CRF receptor types 1, 2α, and 2β; stimulates cAMP accumulation from cells transfected with these receptors. Acts in vitro to release ACTH from rat anterior pituitary cells.
Preparation Note
Urocortin rat dissolves in 1% acetic acid at 1 mg/ml to yield a clear, colorless solution.
Other Notes
Lyophilized from 0.1% TFA in H2O
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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