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U6756

U-73122 hydrate

Name: U-73122 hydrate
Brand: SIGMA

≥97.5% (HPLC), phospholipase C inhibitor, powder

Synonym(s):

1-[6-[((17β)-3-Methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]-1H-pyrrole-2,5-dione

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About This Item

Empirical Formula (Hill Notation):

C₂₉H₄₀N₂O₃ · xH₂O

CAS Number:

112648-68-7

Molecular Weight:

464.64 (anhydrous basis)

UNSPSC Code:

41106300

PubChem Substance ID:

24278065

NACRES:

NA.77

MDL number:

MFCD12910450

Assay:

≥97.5% (HPLC)

Form:

powder

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Properties

Product Name

U-73122 hydrate, powder

assay

≥97.5% (HPLC)

Quality Segment

100

form

powder

color

off-white

solubility

ethanol: ~0.7 mg/mL, DMSO: ~0.9 mg/mL, chloroform: ~10 mg/mL, DMSO: ≤2.6 mg/mL (Achieved with heating.), ethanol: ≤5 mg/mL (Achieved with heating.), H₂O: insoluble

storage temp.

room temp

SMILES string

O.COc1ccc2C3CC[C@]4(C)[C@H](CCC4C3CCc2c1)NCCCCCCN5C(=O)C=CC5=O

InChI

1S/C29H40N2O3.H2O/c1-29-16-15-23-22-10-8-21(34-2)19-20(22)7-9-24(23)25(29)11-12-26(29)30-17-5-3-4-6-18-31-27(32)13-14-28(31)33;/h8,10,13-14,19,23-26,30H,3-7,9,11-12,15-18H2,1-2H3;1H2/t23-,24-,25+,26+,29+;/m1./s1

InChI key

WCOYJDRCHHGMRK-BDEPKWELSA-N

Description

Application

U-73122 hydrate has been used for studying the role of phospholipase C (PLC) signaling in modulating epithelial Na⁺ channel (ENaC) function in gerbil Reissner′s membranes (RMs). U-73122 has also been used to study local calcium responses in human umbilical vein endothelial cells (HUVECs).

Biochem/physiol Actions

Inhibits the hydrolysis of PPI to IP₃, which leads to a decrease in cytosolic free calcium. Inhibits the coupling of G protein-phospholipase C activation, while remaining unaffected by production of cAMP.

Features and Benefits

This compound is featured on the Phospholipase C page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

U-73122 hydrate is soluble in ethanol (approx. 0.7 mg/ml or ≤ 5 mg/ml with heating), chloroform (approx. 10 mg/ml) and DMSO (approx. 0.9 mg/ml or ≤ 2.6 mg/ml with heating). U-73122 hydrate is insoluble in water.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

0000455133

0000445003

0000153720

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Articles

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Global Trade Item Number

SKU	GTIN
U6756-5MG	04061837410000