U6758
UCL 2077
≥98% (HPLC), solid
Synonym(s):
(3-Triphenylmethylaminomethyl)pyridine
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About This Item
Empirical Formula (Hill Notation):
C25H22N2
CAS Number:
Molecular Weight:
350.46
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Quality Level
Assay
≥98% (HPLC)
form
solid
color
white
solubility
DMSO: soluble >20 mg/mL
H2O: insoluble
SMILES string
C(NC(c1ccccc1)(c2ccccc2)c3ccccc3)c4cccnc4
InChI
1S/C25H22N2/c1-4-12-22(13-5-1)25(23-14-6-2-7-15-23,24-16-8-3-9-17-24)27-20-21-11-10-18-26-19-21/h1-19,27H,20H2
InChI key
PQFNWDHABGBCHB-UHFFFAOYSA-N
Application
UCL 2077 has been used for slow afterhyperpolarization (sAHP) studies in thalamic paraventricular nucleus (PVT) neurons. UCL 2077 has also been used for studying its effects on the increase in excitability of hippocampal pyramidal cells.
Biochem/physiol Actions
UCL 2077 is a slow afterhyperpolarization (sAHP) channel blocker.
Preparation Note
UCL 2077 is soluble in DMSO at a concentration >20 mg/ml and is insoluble in water.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Mala M Shah et al.
Molecular pharmacology, 70(5), 1494-1502 (2006-08-01)
The slow afterhyperpolarization (sAHP) in hippocampal neurons has been implicated in learning and memory. However, its precise role in cell excitability and central nervous system function has not been explicitly tested for 2 reasons: 1) there are, at present, no
Li Zhang et al.
Journal of neurophysiology, 104(4), 2052-2062 (2010-08-20)
Thalamic paraventricular nucleus (PVT) neurons exhibit a postburst apamin-resistant slow afterhyperpolarization (sAHP) that is unique to midline thalamus, displays activity dependence, and is abolished in tetrodotoxin. Analysis of the underlying sI(AHP) confirmed a requirement for Ca(2+) influx with contributions from
Hung-Te Hsu et al.
International journal of molecular sciences, 21(4) (2020-02-26)
UCL-2077 (triphenylmethylaminomethyl)pyridine) was previously reported to suppress slow afterhyperpolarization in neurons. However, the information with respect to the effects of UCL-2077 on ionic currents is quite scarce. The addition of UCL-2077 decreased the amplitude of erg-mediated K+ current (IK(erg)) together
James D Angstadt et al.
Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 203(8), 613-633 (2017-05-13)
Postinhibitory rebound (PIR) responses in leech dorsal excitatory motor neurons (cell DE-3) are eliminated by Ca
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