U6758
UCL 2077
≥98% (HPLC), solid
别名:
(3-Triphenylmethylaminomethyl)pyridine
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C25H22N2
化学文摘社编号:
分子量:
350.46
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C25H22N2/c1-4-12-22(13-5-1)25(23-14-6-2-7-15-23,24-16-8-3-9-17-24)27-20-21-11-10-18-26-19-21/h1-19,27H,20H2
SMILES string
C(NC(c1ccccc1)(c2ccccc2)c3ccccc3)c4cccnc4
InChI key
PQFNWDHABGBCHB-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
color
white
solubility
DMSO: soluble >20 mg/mL, H2O: insoluble
Quality Level
Application
UCL 2077 has been used for slow afterhyperpolarization (sAHP) studies in thalamic paraventricular nucleus (PVT) neurons. UCL 2077 has also been used for studying its effects on the increase in excitability of hippocampal pyramidal cells.
Biochem/physiol Actions
UCL 2077 is a slow afterhyperpolarization (sAHP) channel blocker.
Preparation Note
UCL 2077 is soluble in DMSO at a concentration >20 mg/ml and is insoluble in water.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
Mala M Shah et al.
Molecular pharmacology, 70(5), 1494-1502 (2006-08-01)
The slow afterhyperpolarization (sAHP) in hippocampal neurons has been implicated in learning and memory. However, its precise role in cell excitability and central nervous system function has not been explicitly tested for 2 reasons: 1) there are, at present, no
Li Zhang et al.
Journal of neurophysiology, 104(4), 2052-2062 (2010-08-20)
Thalamic paraventricular nucleus (PVT) neurons exhibit a postburst apamin-resistant slow afterhyperpolarization (sAHP) that is unique to midline thalamus, displays activity dependence, and is abolished in tetrodotoxin. Analysis of the underlying sI(AHP) confirmed a requirement for Ca(2+) influx with contributions from
Hung-Te Hsu et al.
International journal of molecular sciences, 21(4) (2020-02-26)
UCL-2077 (triphenylmethylaminomethyl)pyridine) was previously reported to suppress slow afterhyperpolarization in neurons. However, the information with respect to the effects of UCL-2077 on ionic currents is quite scarce. The addition of UCL-2077 decreased the amplitude of erg-mediated K+ current (IK(erg)) together
James D Angstadt et al.
Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 203(8), 613-633 (2017-05-13)
Postinhibitory rebound (PIR) responses in leech dorsal excitatory motor neurons (cell DE-3) are eliminated by Ca
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持