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UC168

(±)-Bufuralol hydrochloride

Name: (±)-Bufuralol hydrochloride
Brand: SIGMA

≥98% (HPLC), solid, β-Adrenoceptor agonist/antagonist

Synonym(s):

α-[(tert-Butylamino)methyl]-7-ethyl-2-benzofuranmethanol hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₂₃NO₂·HCl

CAS Number:

60398-91-6

Molecular Weight:

297.82

NACRES:

NA.77

PubChem Substance ID:

24724644

UNSPSC Code:

12161501

EC Number:

262-216-3

MDL number:

MFCD00272648

Form:

solid

Quality level:

200

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Product Name

(±)-Bufuralol hydrochloride,

form

solid

Quality Level

200

color

white to off-white

mp

143-146 °C

solubility

H₂O: soluble, methanol: soluble

storage temp.

2-8°C

SMILES string

Cl.CCc1cccc2cc(oc12)C(O)CNC(C)(C)C

InChI

1S/C16H23NO2.ClH/c1-5-11-7-6-8-12-9-14(19-15(11)12)13(18)10-17-16(2,3)4;/h6-9,13,17-18H,5,10H2,1-4H3;1H

InChI key

KJBONRGCLLBWCJ-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Application

CYP2D6 substrate

Biochem/physiol Actions

β-Blocker. Varying β-adrenoceptor agonist/antagonist activity.

Bufuralol hydrochloride is known to be a non-specific β-receptor inhibitor that has an affinity for β 1 and β 2 receptors. Furthermore, studies have reported that bufuralol hydrochloride can decrease isoproterenol peripheral resistance.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

(±)-Bufuralol hydrochloride is soluble in water and methanol.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Comparison of cytochrome P450 3A enzymes in cynomolgus monkeys and humans.

Kazuhide Iwasaki et al.

Drug metabolism and pharmacokinetics, 25(4), 388-391 (2010-09-04)

Drug metabolizing activities of cytochromes P450 (P450s, or CYPs) 3A4 and 3A5 in liver microsomes from the cynomolgus monkey [Macaca fascicularis (mf)] were investigated and compared with those of human P450 3A enzymes. Low activities for dealkylation of ethoxyresorufin and

Hemodynamic characterization of bufuralol-HCl and pindolol based on the competitive effects of isoproterenol.

D Magometschnigg et al.

International journal of clinical pharmacology and biopharmacy, 17(11), 429-432 (1979-11-01)

In this hemodynamic study a new beta-receptor blocker, Bufuralol-hydrochloride was compared with Pindolol under an Isoproterenol infusion with increasing doses in healthy male volunteers. We found the following results: 1. Before Isoproterenol peripheral resistance increased after acute i.v. application of

Predictions of cytochrome P450-mediated drug-drug interactions using cryopreserved human hepatocytes: comparison of plasma and protein-free media incubation conditions.

Jialin Mao et al.

Drug metabolism and disposition: the biological fate of chemicals, 40(4), 706-716 (2012-01-10)

Cryopreserved human hepatocytes suspended in human plasma (HHSHP) have previously provided accurate CYP3A drug-drug interaction (DDI) predictions from a single IC(50) that captures both reversible and time-dependent inhibition. The goal of this study was to compare the accuracy of DDI

Rapid and sensitive drug metabolism studies by SU-8 microchip capillary electrophoresis-electrospray ionization mass spectrometry.

Nina Nordman et al.

Journal of chromatography. A, 1218(5), 739-745 (2010-12-28)

Monolithically integrated, polymer (SU-8) microchips comprising an electrophoretic separation unit, a sheath flow interface, and an electrospray ionization (ESI) emitter were developed to improve the speed and throughput of metabolism research. Validation of the microchip method was performed using bufuralol

D₂-dopaminergic receptor-linked pathways: critical regulators of CYP3A, CYP2C, and CYP2D.

Evangelos P Daskalopoulos et al.

Molecular pharmacology, 82(4), 668-678 (2012-07-10)

Various hormonal and monoaminergic systems play determinant roles in the regulation of several cytochromes P450 (P450s) in the liver. Growth hormone (GH), prolactin, and insulin are involved in P450 regulation, and their release is under dopaminergic control. This study focused

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Global Trade Item Number

SKU	GTIN
UC168-10MG	04061832931746
UC168-5MG	04061837410185

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