Name: Midazolam hydrochloride
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₁₃ClFN₃ · HCl

CAS Number:

59467-96-8

Molecular Weight:

362.23

EC Number:

261-776-6

MDL number:

MFCD00864445

UNSPSC Code:

12161501

PubChem Substance ID:

24724654

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form

solid

drug control

USDEA Schedule IV; Home Office Schedule 3; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

color

white to off-white

solubility

H₂O: soluble at least 1 mg/mL

storage temp.

2-8°C

SMILES string

Cc1ncc2CN=C(c3ccccc3F)c4cc(Cl)ccc4-n12

InChI

1S/C18H13ClFN3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3

InChI key

DDLIGBOFAVUZHB-UHFFFAOYSA-N

Gene Information

human ... ABCB1(5243), CYP3A4(1576), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879)
mouse ... Abcb1a(18671), Abcb1b(18669)
rat ... Gabbr1(81657), Gabra1(29705)

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Application

Midazolam has been used as an anesthetic for surgical experiments in rats. This anesthetic has also been used in rats to study the interactions between midazolam and bupivacaine.

Biochem/physiol Actions

Sedative/hypnotic; ligand for the GABA_A receptor benzodiazepine modulatory site; CYP3A4 substrate.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Midazolam hydrochloride is soluble in water to at least 1 mg/ml. Product solutions should be protected from light.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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