UC432
AAMU
Synonym(s):
5-Acetylamino-6-amino-3-methyluracil, N-(4-Amino-1,2,3,6-tetrahydro-1-methyl-2,6-dioxo-5-pyrimidinyl)acetimide
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About This Item
Empirical Formula (Hill Notation):
C7H10N4O3
CAS Number:
Molecular Weight:
198.18
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
MDL number:
Form:
solid
form
solid
color
white to light pink
mp
≥305 °C
storage temp.
2-8°C
SMILES string
CN1C(=O)NC(N)=C(NC(C)=O)C1=O
InChI
1S/C7H10N4O3/c1-3(12)9-4-5(8)10-7(14)11(2)6(4)13/h8H2,1-2H3,(H,9,12)(H,10,14)
InChI key
POQOTWQIYYNXAT-UHFFFAOYSA-N
Application
CYP1A2 metabolite of caffeine
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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M E Morris et al.
Clinical pharmacology and therapeutics, 46(3), 359-366 (1989-09-01)
Little is known regarding the biotransformation of drugs in Down's syndrome. In particular, there are no published studies that examine metabolic pathways such as N-acetylation, which can exhibit genetically-determined variability. The objective of the present investigation was to compare the
A J Kilbane et al.
Clinical pharmacology and therapeutics, 47(4), 470-477 (1990-04-01)
The human acetylation genotype was determined by measuring urinary caffeine metabolites by use of a modification of a previously published HPLC method. The problem of separation of 7-methylxanthine (7X) from 1-methyluric acid (IU) in urine extracts was achieved by adding
Y Kawakubo et al.
Dermatology (Basel, Switzerland), 195(1), 43-45 (1997-01-01)
p-Phenylenediamine (PPD) has been widely distributed as hair dye ingredient and may be responsible for contact dermatitis. Since not all the subjects exposed to PPD react to the substance, we tested a possible predisposing factor of cutaneous drug metabolism. Eighty-five
B K Tang et al.
Clinical pharmacology and therapeutics, 49(6), 648-657 (1991-06-01)
The use of two caffeine metabolite ratios for acetylator phenotyping was validated by demonstrating concordance with two sulfamethazine tests in 178 unrelated healthy subjects. The caffeine metabolites used for this purpose were 5-acetylamino-6-amino-3-methyluracil (AAMU), 1-methylxanthine (1X), and 1-methylurate (1U). The
B K Tang et al.
Clinical pharmacology and therapeutics, 42(5), 509-513 (1987-11-01)
Previously published methods allow the determination of the genetically controlled acetylator status using caffeine as a test drug, based on the urinary excretion of a ring-opened metabolite of caffeine, an acetylated uracil (5-acetylamino-6-formylamino-3-methyluracil). 5-Acetylamino-6-formylamino-3-methyluracil is labile but can be converted
Related Content
Global Trade Item Number
| SKU | GTIN |
|---|---|
| UC432-5MG | 04061832932231 |
| UC432-10MG | 04061832932224 |
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