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V3765

VU0255035 hydrate

Name: VU0255035 hydrate
Brand: SIGMA

≥98% (HPLC)

Synonym(s):

CID24768606, ML012, N-(3-oxo-3-(4-(pyridine-4-yl)piperazin-1-yl)propyl)benzo[c][1,2,5]thiadiazole-4-sulfonamide hydrate, N-[3-oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide hydrate

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₂₀N₆O₃S₂ · xH₂O

CAS Number:

1135243-19-4

Molecular Weight:

432.52 (anhydrous basis)

NACRES:

NA.77

PubChem Substance ID:

329829045

UNSPSC Code:

12352200

MDL number:

MFCD16875440

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Properties

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

yellow

solubility

DMSO: >5 mg/mL

storage temp.

−20°C

SMILES string

O.O=C(CCNS(=O)(=O)c1cccc2nsnc12)N3CCN(CC3)c4ccncc4

InChI

1S/C18H20N6O3S2.H2O/c25-17(24-12-10-23(11-13-24)14-4-7-19-8-5-14)6-9-20-29(26,27)16-3-1-2-15-18(16)22-28-21-15;/h1-5,7-8,20H,6,9-13H2;1H2

InChI key

NURHGMDBQMBSQI-UHFFFAOYSA-N

Description

Biochem/physiol Actions

VU0255035 is the first highly selective antagonist at the orthosteric site of the M1 receptor (75-fold selective for M1 relative to other muscarininc subtypes and devoid of activity at other GPCRs, ion channels, transporters and kinases). There are no highly selective M1 muscarinic receptor antagonists. The existing non-selective drugs do not permit direct evaluation of the role of M1 receptors in CNS fucntions and do not premit therapeutic targeting of M1 receptors in various disease states in which M1 receptors are implicated (epilepsy, Parkinson′s disease, attention and cognitive disorders, dystonia, etc).

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.