V5765
Vascular Endothelial Growth Factor 165 human
≥95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized powder, suitable for cell culture
Synonym(s):
Vascular Endothelial Growth Factor 165
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.77
Biological source:
human
Recombinant:
expressed in HEK 293 cells
Assay:
≥95% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
dimer 42 kDa (glycosylated)
Impurities:
<0.075 EU/μg
Product Name
VEGF165, recombinant, expressed in HEK 293 cells, suitable for cell culture
biological source
human
recombinant
expressed in HEK 293 cells
description
Vascular Endothelial Growth Factor 165 human
assay
≥95% (SDS-PAGE)
form
lyophilized powder
potency
<10 ng/mL ED50
quality
endotoxin tested
mol wt
dimer 42 kDa (glycosylated)
packaging
pkg of 10 μg, pkg of 50 μg
technique(s)
cell culture | mammalian: suitable
impurities
<0.075 EU/μg
color
white
solubility
water: soluble
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... VEGFA(7422)
General description
VEGF165 is expressed in human HEK 293 cells as a glycosylated homodimer with an apparent molecular mass of 45 kDa. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.
Biochem/physiol Actions
VEGF165 belongs to the PDGF/VEGF growth factor family characterized by the presence of eight conserved cysteine residues and a cystine knot structure. VEGF is secreted by the majority of tumor cells and initiates angiogenesis by activating endothelial cells of existing blood vessels and promoting their migration.
VEGF has also been implicated in correlation with poor prognosis in breast cancer.
In addition, VEGF is released in rheumatoid arthritis in response to TNF-α, increasing endothelial permeability and stimulating angiogenesis (formation of capillaries).
VEGF has also been implicated in correlation with poor prognosis in breast cancer.
In addition, VEGF is released in rheumatoid arthritis in response to TNF-α, increasing endothelial permeability and stimulating angiogenesis (formation of capillaries).
Analysis Note
The specific activity was determined by the dose-dependent stimulation of the proliferation of HUVEC cells (human umbilical vein endothelial cells).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Cheng Wang et al.
Nature communications, 12(1), 2616-2616 (2021-05-12)
FUN14 domain-containing protein 1 (FUNDC1) is an integral mitochondrial outer-membrane protein, and mediates the formation of mitochondria-associated endoplasmic reticulum membranes (MAMs). This study aims to determine the contributions of FUNDC1-mediated MAMs to angiogenesis in vitro and in vivo. In cultured
Lee M Ellis
Hematology/oncology clinics of North America, 18(5), 1007-1021 (2004-10-12)
This article focuses on the preclinical evidence for activation of the epidermal growth factor receptor (EGFR) in promoting angiogenesis and the efficacy of anti-EGFR agents in inhibiting angiogenesis and tumor growth.
A O Afuwape et al.
Histology and histopathology, 17(3), 961-972 (2002-08-10)
The expansion of the synovial lining of joints in rheumatoid arthritis (RA), and the subsequent invasion by the pannus of underlying cartilage and bone, necessitates an increase in the vascular supply to the synovium, to cope with the increased requirement
Xiaoqiang Tang
Cancer letters, 332(1), 3-10 (2013-01-26)
Breast cancer development largely depends upon the essential contributions from the tumor microenvironment, where several inflammatory cell populations (e.g. macrophages) orchestrate breast cancer development. The majority of tumor-associated macrophages (TAMs) exhibit alternatively activated M2 properties, produce abundant anti-inflammatory factors and
C J Robinson et al.
Journal of cell science, 114(Pt 5), 853-865 (2001-02-22)
Vascular endothelial growth factor (VEGF) is a secreted mitogen highly specific for cultured endothelial cells. In vivo VEGF induces microvascular permeability and plays a central role in both angiogenesis and vasculogenesis. VEGF is a promising target for therapeutic intervention in
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