V6633
VEGF Receptor-3 (Flt-4)/Fc Chimera from mouse
>95% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder
Synonym(s):
Vascular Endothelial Growth Factor Receptor‑3
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
UNSPSC Code:
12352202
MDL number:
Biological source:
mouse
Recombinant:
expressed in baculovirus infected Sf21 cells
Assay:
>95% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
110-120 kDa by SDS-PAGE (glycosylation), calculated mol wt ~84.5 kDa
Impurities:
endotoxin, tested
biological source
mouse
recombinant
expressed in baculovirus infected Sf21 cells
assay
>95% (SDS-PAGE)
form
lyophilized powder
mol wt
110-120 kDa by SDS-PAGE (glycosylation), calculated mol wt ~84.5 kDa
packaging
pkg of 1 mg
storage condition
avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Flt4(14257)
Application
VEGF Receptor-3 (Flt-4)/Fc Chimera from mouse is a disulfide-linked homodimeric protein consist of VEGF Receptor-3 fused with6X histidine tagged Fc portion of human IgG1 by a polypeptide linker. It may be used as a specific marker for lymphatic vessels as well as plays a pivotal role in the development of the lymphatic vessel system. The product was used to study the novel technique for pharmacological manipulation of blood and lymphatic vascularization in cultured mouse embryos ex vivo.
Biochem/physiol Actions
VEGF Receptor-3 (Flt-4) belongs to class III subfamily of RTKs and is expressed mainly in endothelial cells. VEGF Receptor-3 can block VEGF-C/D and inhibits lymphangiogenesis and lymphatic metastasis in orthotopic urinary bladder cancer (OUBC).
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline
Analysis Note
The activity is measured by its ability to bind human VEGF-D.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Hanseul Yang et al.
Molecular cancer, 10, 36-36 (2011-04-13)
Most bladder cancer patients experience lymphatic metastasis in the course of disease progression, yet the relationship between lymphangiogenesis and lymphatic metastasis is not well known. The aim of this study is to elucidate underlying mechanisms of how expanded lymphatic vessels
Ayako Fujiwara et al.
Lung cancer (Amsterdam, Netherlands), 106, 8-16 (2017-03-14)
Epithelial to mesenchymal transition (EMT) relates to both organ fibrosis and malignant behavior of cancer. Pirfenidone (PFD) is an anti-fibrotic agent for idiopathic pulmonary fibrosis and one of its functions may be to inhibit fibrotic EMT. This study aimed to
Martin Zeeb et al.
Nature protocols, 7(11), 1970-1982 (2012-10-13)
Formation of new blood and lymphatic vessels is involved in many physiological and pathological processes, including organ and tumor growth, cancer cell metastasis, fluid drainage and lymphedema. Therefore, the ability to manipulate vascularization in a mammalian system is of particular
Related Content
Global Trade Item Number
| SKU | GTIN |
|---|---|
| V6633-.1MG | 04061832277837 |
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service