W4387
Wee1, active from rat
N-terminal GST-tagged, solution
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About This Item
Biological source:
rat
Recombinant:
expressed in E. coli
biological source
rat
Quality Segment
recombinant
expressed in E. coli
form
solution
mol wt
~110 kDa
UniProt accession no.
application(s)
cell analysis
shipped in
dry ice
storage temp.
−70°C
Gene Information
rat ... Wee1(308937)
Application
Wee1, active from rat may be used to study apoptotic signaling.
Biochem/physiol Actions
Protein inhibitor of Cdk2 kinase
Wee1 is a protein tyrosine kinase that phosphorylates Cdc2 on Tyr15 and hence inactivates the CDK1 and CDK2, which facilitates in the negative regulation of entry of cells into mitosis. Increased level of wee1 stimulates Human Immunodeficiency Virus type 1 (HIV-1) Vpr induced cell cycle arrest at G2/M transition followed by apoptosis.
Physical form
Solution in 50 mM Tris-HCl, pH 7.5, 1 mM EDTA, 1 mM DTT, 10% Glycerol
Other Notes
One unit of Wee 1 is defined as the amount of Wee 1 which inhibits 90% of the activity of 10 units of Cdk2
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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