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Merck
CN

WH0004647M1

Monoclonal Anti-MYO7A antibody produced in mouse

clone 1D3, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-DFNA11, Anti-DFNB2, Anti-MYU7A, Anti-NSRD2, Anti-USH1B, Anti-myosin VIIA

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD02263784
Conjugate:
unconjugated
Clone:
1D3, monoclonal
Application:
ELISA (i)
Citations:
3

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

1D3, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: suitable

isotype

IgG1κ

GenBank accession no.

NM_000260

UniProt accession no.

Q13402

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... MYO7A(4647)

General description

MYO7A (myosin VIIA) or HM7A consists of 5 isoleucine-glutamine (IQ) motifs. It is present in retinal epithelial cells. It also interacts with other USH1 (Usher syndrome type 1B) gene products like harmonin and sans. This gene is located on human chromosome 11q13.

Immunogen

MYO7A (NP_000251, 2118 a.a. ~ 2213 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
KQTTEPNFPEILLIAINKYGVSLIDPKTKDILTTHPFTKISNWSSGNTYFHITIGNLVRGSKLLCETSLGYKMDDLLTSYISQMLTAMSKQRGSRS

Biochem/physiol Actions

MYO7A (myosin VIIA) or HM7A is involved in anchoring and holding membrane-bound elements to the actin core of the stereocilium. It acts as a transporter. This protein may participate in the tethering of melanosomes at the root of actin bundles. HM7A is responsible for Usher syndrome type 1B. In mice and humans, alteration in Myo7a causes hereditary deafness.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
06237-1D3

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The genomic structure of the gene defective in Usher syndrome type Ib (MYO7A)
Kelley PM, et al.
Genomics, 40(1), 73-79 (1997)
Structure and Regulation of the Movement of Human Myosin VIIA
Sakai T, et al.
The Journal of Biological Chemistry, 17587-17598 (2015)
Reduced climbing and increased slipping adaptation in cochlear hair cells of mice with Myo7a mutations
Kros CJ, et al.
Nature Neuroscience (2002)

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