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Merck
CN

WH0005692M1

Monoclonal Anti-PSMB4 antibody produced in mouse

clone 6G7-E8, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-HN3, Anti-HsN3, Anti-PROS26, Anti-proteasome (prosome, macropain) subunit, beta type, 4

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

6G7-E8, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL

isotype

IgG1κ

GenBank accession no.

BC000331

UniProt accession no.

P28070

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PSMB4(5692)

General description

Proteasome subunit β 4 (PSMB4), also referred to as 20S proteasome subunit β-7, is a non-catalytic β subunit of the 20S proteasome. It is composed of 233 amino acids and the gene encoding it is localized on human chromosome 1q21.3.

Immunogen

PSMB4 (AAH00331, 1 a.a. ~ 264 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MEAFLGSRSGLWAGGPAPGQFYRIPSTPDSFMDPASALYRGPITRTQNPMVTGTSVLGVKFEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQVLGQMVIDEELLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVDMLGVAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDARSYNRFQTATVTEKGVEIEGPLSTETNWDIAHMISGFE

Biochem/physiol Actions

Proteasome subunit β 4 (PSMB4) associates with senescence evasion factor (SNEV), various signaling factors, viral proteins and lipopolysaccharides. It modulates the assembly of the proteasome and may be involved in proteasome signal regulation. PSMB4 has a role in the progression of epithelial ovarian cancer and many other types of cancers.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
06104-S1

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Comparative Oncogenomics Identifies PSMB4 and SHMT2 as Potential Cancer Driver Genes
Genne Y
Cancer Research (2014)
The ubiquitin-proteasome system and chromosome 17 in cerebellar granule cells and medulloblastoma subgroups
Jerry V
Cellular and Molecular Life Sciences (2016)
Interaction of U-box E3 ligase SNEV with PSMB4, the beta7 subunit of the 20 S proteasome.
Losher M
The Biochemical Journal (2005)
PSMB4 expression associates with epithelial ovarian cancer growth and poor prognosis.
Archives of Gynecology and Obstetrics (2016)
Cloning and expression of a human pro(tea)some beta-subunit cDNA: a homologue of the yeast PRE4-subunit essential for peptidylglutamyl-peptide hydrolase activity.
Gerards WL
Febs Letters (1994)

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