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Merck
CN

WH0010014M1

Monoclonal Anti-HDAC5 antibody produced in mouse

clone 4G2, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-HD5, Anti-NYCO9, Anti-histone deacetylase 5

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD04040361
Conjugate:
unconjugated
Clone:
4G2, monoclonal
Application:
ELISA (i), IF, WB
Citations:
2

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

4G2, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: suitable, indirect immunofluorescence: suitable, western blot: 1-5 μg/mL

isotype

IgG1κ

GenBank accession no.

BC051824

UniProt accession no.

Q9UQL6

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... HDAC5(10014)

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Immunogen

HDAC5 (AAH51824, 330 a.a. ~ 429 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
AENGFTGSVPNIPTEMLPQHRALPLDSSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLG

Biochem/physiol Actions

Histone deacetylase 5 (HDAC5) promotes progression of the cell cycle, cell proliferation and apoptosis. Reduced expression of the protein is observed in colon cancer and acute myeloid leukemia.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

低风险生物材料
常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
08283-4G2
07040-4G2

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HDAC5 is required for maintenance of pericentric heterochromatin, and controls cell-cycle progression and survival of human cancer cells.
Peixoto P
Cell Death and Differentiation, 19(7), 1239-1252 (2012)
Formononetin sensitizes glioma cells to doxorubicin through preventing EMT via inhibition of histone deacetylase 5.
Liu Q
International Journal of Clinical and Experimental Pathology, 8(6), 6434-6441 (2015)

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