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Merck
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WH0055144M1

Monoclonal Anti-LRRC8D antibody produced in mouse

clone 3H1-1C2, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-FLJ10470, Anti-FLJ20403, Anti-leucine rich repeat containing 5

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
3H1-1C2, monoclonal
Application:
ELISA (i), WB
Citations:
4

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

3H1-1C2, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: suitable, western blot: 1-5 μg/mL

isotype

IgG1κ

GenBank accession no.

BC009486

UniProt accession no.

Q7L1W4

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... LRRC8D(55144)

Related Categories

General description

Leucine rich repeat containing 8 VRAC subunit D (LRRC8D) is a mammalian protein, which belongs to the family of leucine-rich repeat-containing 8 (LRRC8). It consists of four transmembrane domains at the N terminal and 17 leucine-rich repeats (LRR) at the C terminal. The gene is located on human chromosome 1p22.2.

Immunogen

LRRC5 (AAH09486, 1 a.a. ~ 143 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MVSSNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVSTSSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVEDSDLIYKLYVVQTASPFPNQ

Biochem/physiol Actions

Leucine rich repeat containing 8 VRAC subunit D (LRRC8D) is important for the translocation of neutral compounds like myo-inositol, taurine, γ-aminobutyric acid (GABA) and prolonged transport of positively charged lysine. LRRC8D deficiency is associated with reduced cellular platinum level. The protein acts as a transporter of small molecules. It is essential for the import of the antibiotic blasticidin S.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
06062-S1

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Selective transport of neurotransmitters and--modulators by distinct volume-regulated LRRC8 anion channels
Lutter D, et al.
Journal of Cell Science, jcs-196253 (2017)
Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways
Nishimura Y, et al.
Human Molecular Genetics, 16(14), 1682-1698 (2007)
VRACs swallow platinum drugs
Voets T, et al.
The Embo Journal, e201593357-e201593357 (2015)
The protein synthesis inhibitor blasticidin s enters mammalian cells via leucine-rich repeat-containing protein 8D
Lee CC, et al.
The Journal of Biological Chemistry, jbc-M114 (2014)

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