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Merck
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WH0376267M1

Monoclonal Anti-RAB15 antibody produced in mouse

clone 1G12, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-RAB15, member RAS onocogene family

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
1G12, monoclonal
Application:
ELISA (i), WB
Citations:
2

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

1G12, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: suitable, western blot: 1-5 μg/mL

isotype

IgG2aκ

GenBank accession no.

BC040679

UniProt accession no.

P59190

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... RAB15(376267)

General description

Member of RAS oncogene family, RAB15 is a GTPase expressed in the brain.

Immunogen

RAB15 (AAH40679, 99 a.a. ~ 208 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
IMKWVSDVDEVGDATSLPGCGEGASPGKARRGPDGKANASRKLCLPQPWMKTSGTHQKASRRSLLGIRLMRSRNGRWEESKGSSWRRSMAWTSMKQVPAPTSTLKSHSRV

Biochem/physiol Actions

Member of RAS oncogene family, RAB15, has a role in endocytosis. It is a target of the protein atonal homolog 1 (Atoh1), a neural transcription factor. RAB15 has been linked to neuroblastoma.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
06265-1G12

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Thi Van Huyen Pham et al.
Oncology reports, 27(6), 2045-2049 (2012-03-20)
Neuroblastoma is an aggressive pediatric tumor that accounts for 15% of cancer-related deaths in children. More than half of high-risk neuroblastoma patients develop tumor relapse that is lethal in most cases. A small population of tumor-initiating cells (TICs), recently identified
David J Strick et al.
Molecular biology of the cell, 16(12), 5699-5709 (2005-10-01)
Sorting endosomes and the endocytic recycling compartment are critical intracellular stores for the rapid recycling of internalized membrane receptors to the cell surface in multiple cell types. However, the molecular mechanisms distinguishing fast receptor recycling from sorting endosomes and slow

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