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Merck
CN

WH0404037M2

Monoclonal Anti-HAPLN4 antibody produced in mouse

clone 1C1, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-BRAL2, Anti-KIAA1926, Anti-hyaluronan and proteoglycan link protein 4

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
1C1, monoclonal
Application:
ELISA (i), WB
Citations:
3

Key Documents

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storage temp.

−20°C

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

1C1, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: suitable, western blot: 1-5 μg/mL

isotype

IgG2bκ

GenBank accession no.

NM_023002

UniProt accession no.

Q86UW8

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... HAPLN4(404037)

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General description

Hyaluronan and proteoglycan link protein 4 (HAPLN4) is expressed in the brain.

Immunogen

HAPLN4 (NP_075378, 30 a.a. ~ 134 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
QRGRKKVVHVLEGESGSVVVQTAPGQVVSHRGGTIVLPCRYHYEAAAHGHDGVRLKWTKVVDPLAFTDVFVALGPQHRAFGSYRGRAELQGDGPGDASLVLRNVT

Biochem/physiol Actions

Hyaluronan and proteoglycan link protein 4 (HAPLN4) takes part in the development of the extracellular matrix. It also has a role in adhesion and migration of glioma cells. HAPLN4 aids in the association of hyaluronan with other proteins like aggrecan.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
07334-1C1

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Yoko Bekku et al.
Molecular and cellular neurosciences, 24(1), 148-159 (2003-10-11)
The hyaluronan binding chondroitin sulphate proteoglycans, called lecticans, are the abundant extracellular matrix molecules in the developing and/or adult brain. The link proteins (LPs) are also known to be coordinately present in brain. We report here the molecular cloning and
Hosung Sim et al.
The Journal of biological chemistry, 284(39), 26547-26556 (2009-07-28)
Malignant gliomas have a distinctive ability to infiltrate the brain parenchyma and disrupt the neural extracellular matrix that inhibits motility of axons and normal neural cells. Chondroitin sulfate proteoglycans (CSPGs) are among the major inhibitory components in the neural matrix
Anna K Kähler et al.
Biological psychiatry, 69(1), 90-96 (2010-10-19)
The Human Natural Killer-1 carbohydrate (HNK-1) is involved in neurodevelopment and synaptic plasticity. Extracellular matrix structures called perineuronal nets, condensed around subsets of neurons and proximal dendrites during brain maturation, regulate synaptic transmission and plasticity. Ten genes of importance for

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