WH0404037M2
Monoclonal Anti-HAPLN4 antibody produced in mouse
clone 1C1, purified immunoglobulin, buffered aqueous solution
别名:
Anti-BRAL2, Anti-KIAA1926, Anti-hyaluronan and proteoglycan link protein 4
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
1C1, monoclonal
Application:
ELISA (i), WB
Citations:
3
storage temp.
−20°C
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
1C1, monoclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
indirect ELISA: suitable, western blot: 1-5 μg/mL
isotype
IgG2bκ
GenBank accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HAPLN4(404037)
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General description
Hyaluronan and proteoglycan link protein 4 (HAPLN4) is expressed in the brain.
Immunogen
HAPLN4 (NP_075378, 30 a.a. ~ 134 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
QRGRKKVVHVLEGESGSVVVQTAPGQVVSHRGGTIVLPCRYHYEAAAHGHDGVRLKWTKVVDPLAFTDVFVALGPQHRAFGSYRGRAELQGDGPGDASLVLRNVT
Sequence
QRGRKKVVHVLEGESGSVVVQTAPGQVVSHRGGTIVLPCRYHYEAAAHGHDGVRLKWTKVVDPLAFTDVFVALGPQHRAFGSYRGRAELQGDGPGDASLVLRNVT
Biochem/physiol Actions
Hyaluronan and proteoglycan link protein 4 (HAPLN4) takes part in the development of the extracellular matrix. It also has a role in adhesion and migration of glioma cells. HAPLN4 aids in the association of hyaluronan with other proteins like aggrecan.
Physical form
Solution in phosphate buffered saline, pH 7.4
Legal Information
GenBank is a registered trademark of United States Department of Health and Human Services
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Yoko Bekku et al.
Molecular and cellular neurosciences, 24(1), 148-159 (2003-10-11)
The hyaluronan binding chondroitin sulphate proteoglycans, called lecticans, are the abundant extracellular matrix molecules in the developing and/or adult brain. The link proteins (LPs) are also known to be coordinately present in brain. We report here the molecular cloning and
Hosung Sim et al.
The Journal of biological chemistry, 284(39), 26547-26556 (2009-07-28)
Malignant gliomas have a distinctive ability to infiltrate the brain parenchyma and disrupt the neural extracellular matrix that inhibits motility of axons and normal neural cells. Chondroitin sulfate proteoglycans (CSPGs) are among the major inhibitory components in the neural matrix
Anna K Kähler et al.
Biological psychiatry, 69(1), 90-96 (2010-10-19)
The Human Natural Killer-1 carbohydrate (HNK-1) is involved in neurodevelopment and synaptic plasticity. Extracellular matrix structures called perineuronal nets, condensed around subsets of neurons and proximal dendrites during brain maturation, regulate synaptic transmission and plasticity. Ten genes of importance for
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