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Key Documents

COO/COA

WH0414899M5

Monoclonal Anti-BRCC2 antibody produced in mouse

Name: Monoclonal Anti-BRCC2 antibody produced in mouse
Brand: SIGMA

clone 3F4, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-BRCC2

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About This Item

MDL number:

MFCD01321778

UNSPSC Code:

12352203

NACRES:

NA.43

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

3F4, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunofluorescence: suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL

isotype

IgG2aκ

GenBank accession no.

NM_001001786

UniProt accession no.

Q8IZY5

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... BLID(414899)

General description

This gene encodes a BH3-like motif containing protein involved in cell death. The encoded protein may induce apoptosis in a caspase-dependent manner. The protein is localized in both the cytoplasm and the mitochondrion. [SH

Immunogen

BRCC2 (NP_001001786, 2 a.a. ~ 108 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
VTLLPIEGQEVHFFEILESECVLYTGWIERASGSSIYPEAKARLPLEALLGSNKEPMLPKETVLSLKRYNLGSSAMKRNVPGHVLQRPSYLTRIQVTLLCNSSAEAL

Biochem/physiol Actions

BRCC2 or BH3-like motif containing, cell death inducer acts as a tumor suppressor by modulating the AKT8 virus oncogene cellular homolog (Akt) pathway in breast cancer tissue. It associates with Bcl-2 long isoform (BCL-XL). BRCC2 also stimulates the caspase-dependent mitochondrial cell death pathway.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

07205-3F4

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