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X1126

Xylazine

Name: Xylazine
Brand: SIGMA

≥99%, Alpha-2 adrenergic agonist

Synonym(s):

2-(2,6-Dimethylphenylamino)-5,6-dihydro-4H-thiazine

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₁₆N₂S

CAS Number:

7361-61-7

Molecular Weight:

220.33

NACRES:

NA.77

PubChem Substance ID:

24902128

UNSPSC Code:

12352200

EC Number:

230-902-1

MDL number:

MFCD00057908

Assay:

≥99%

Quality level:

200

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Product Name

Xylazine, ≥99%

Quality Level

200

assay

≥99%

drug control

Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet

storage temp.

−20°C

SMILES string

Cc1cccc(C)c1NC2=NCCCS2

InChI

1S/C12H16N2S/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12/h3,5-6H,4,7-8H2,1-2H3,(H,13,14)

InChI key

BPICBUSOMSTKRF-UHFFFAOYSA-N

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General description

Xylazine is soluble in methanol (50 mg/ml), yielding a clear, colorless solution. It is also soluble in dilute HCl acid and in chloroform. Xylazine is practically insoluble in water and in alkali solutions.

Application

Xylazine has been used to anaesthetise experimental animals.

Biochem/physiol Actions

Xylazine when used along with ketamine is considered to be a potent and safe anaesthetic in experimental animal. It is known to elevate the hepatic release of glucose, which aggravates to hyperglycemia.

α₂-adrenoceptor agonist, sedative, muscle relaxant.

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Information

监管及禁止进口产品

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MIND model for triple-negative breast cancer in syngeneic mice for quick and sequential progression analysis of lung metastasis

Ghosh A, et al.

PLoS ONE, 13(5), e0198143-e0198143 (2018)

Acute reversible cataract induced by xylazine and by ketamine-xylazine anesthesia in rats and mice

Calderone L, et al.

Experimental Eye Research, 42(4), 331-337 (1986)

Effect of xylazine on plasma glucose, glucagon and insulin concentrations in sheep

Brockman, RP

Research in Veterinary Science, 30(3), 383-384 (1981)

Imaging of rat optic nerve axons in vivo

Koch JC, et al.

Nature Protocols, 6(12), 1887-1887 (2011)

Macrophage dynamics are regulated by local macrophage proliferation and monocyte recruitment in injured pancreas.

Naomi Van Gassen et al.

European journal of immunology, 45(5), 1482-1493 (2015-02-04)

Pancreas injury by partial duct ligation (PDL) activates a healing response, encompassing β-cell neogenesis and proliferation. Macrophages (MΦs) were recently shown to promote β-cell proliferation after PDL, but they remain poorly characterized. We assessed myeloid cell diversity and the factors

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Global Trade Item Number

SKU	GTIN
X1126-1G	04061837544491
X1126-5G	04061837544644

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