X2502
Xanthine sodium salt
≥99%
Synonym(s):
2,6-Dihydroxypurine
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About This Item
Empirical Formula (Hill Notation):
C5H3N4NaO2
CAS Number:
Molecular Weight:
174.09
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
Assay:
≥99%
Biological source:
synthetic (organic)
Form:
powder
Solubility:
dilute NaOH: soluble, clear to slightly hazy
biological source
synthetic (organic)
Quality Level
assay
≥99%
form
powder
impurities
≤4% total solvent
solubility
dilute NaOH: soluble, clear to slightly hazy
SMILES string
[Na].O=C1NC(=O)c2[nH]cnc2N1
InChI
1S/C5H4N4O2.Na.H/c10-4-2-3(7-1-6-2)8-5(11)9-4;;/h1H,(H3,6,7,8,9,10,11);;
InChI key
JAZQMXVZANZJSO-UHFFFAOYSA-N
General description
Xanthine is an intermediate of purine nucleotide metabolism. It is found in most body tissues and fluids. Xanthine derivatives are present in coffee, tea, and chocolate.
Application
Xanthine sodium salt has been used as a component of substrate solution for xanthine oxidase during superoxide dismutase (SOD) assay. It has also been used as a supplement in a special-conditioned medium to culture Swiss 3T3 fibroblasts stably transfected with tetracycline (tet)-controlled transactivator and transactivator-controlled tissue transglutaminase cDNA [39] constructs (clone TG3).
Biochem/physiol Actions
Xanthine acts as a substrate for xanthine oxidase. It elevates cellular cyclic AMP levels by preventing its breakdown and metabolism by inhibition of tissue phosphodiesterases. Xanthine also exhibits anti-inflammatory properties either by the release of anti-inflammatory cytokines or gene transcription regulation or histone deacetylase activation. All these properties of xanthine aid in the relaxation of smooth muscles of the bronchial tree.
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signalword
Warning
hcodes
Hazard Classifications
STOT SE 2
target_organs
Eyes,Central nervous system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Articles
Uric acid present in animal sera impacts serum-supplemented classical cell culture systems, influencing cell culture performance.
Munevver B Cicekdal et al.
IUBMB life, 71(12), 1973-1985 (2019-08-20)
Calorie restriction (CR) is one of the most effective methods to prevent many diseases including cancer in preclinical models. However, the molecular mechanism of how CR prevents cancer is unclear. The aim of this study was to understand the role
Nitrosylation of tissue transglutaminase enhances fibroblast migration and regulates MMP activation.
İnci Kurt-Celep et al.
Matrix biology : journal of the International Society for Matrix Biology, 105, 1-16 (2021-11-12)
In wound healing, the TG2 enzyme plays a dual functional role. TG2 has been shown to regulate extracellular matrix (ECM) stabilization by its transamidase activity while increasing cell migration by acting as a cell adhesion molecule. In this process, nitric
Global Trade Item Number
| SKU | GTIN |
|---|---|
| X2502-10G | 04061833632697 |
| X2502-5G | 04061837545405 |
| X2502-25G | 04061837545368 |