X2628
Xestospongin C
IP3 receptor Inhibitor, film
Synonym(s):
XeC
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About This Item
Linear Formula:
C28 H50 N2 O2
CAS Number:
Molecular Weight:
446.71
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
film
Quality level:
Product Name
Xestospongin C, film
form
film
Quality Level
color
colorless
solubility
DMSO: soluble
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@@]12CCCCCC[C@@]3([H])CCCN4CC[C@@]([H])(CCCCCC[C@]5([H])CCCN(CC1)[C@@]5([H])O2)O[C@@]34[H]
InChI
1S/C28H50N2O2/c1-3-7-15-25-17-21-30-20-10-14-24(28(30)31-25)12-6-2-4-8-16-26-18-22-29-19-9-13-23(11-5-1)27(29)32-26/h23-28H,1-22H2/t23-,24+,25-,26-,27+,28+/m1/s1
InChI key
PQYOPBRFUUEHRC-HCKQMYSWSA-N
General description
Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge.
Biochem/physiol Actions
Xestospongin C is a potent, reversible and membrane-permeable blocker of IP3-mediated Ca2+ release (IC50=358 nM).
Xestospongin C is a selective, reversible and membrane-permeable inhibitor of IP3 receptor. Reversibly blocks bradykinin- and carbamylcholine- Ca2+ efflux from the endoplasmic reticulum stores.
Features and Benefits
This compound is featured on the InsP3/Ryanodine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Packaging
Package under nitrogen, tightly sealed.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Related Content
S Miyamoto et al.
British journal of pharmacology, 130(3), 650-654 (2000-05-24)
We evaluated the role of the inositol 1,4,5-triphosphate (IP(3)) receptor-mediated Ca(2+) release on the positive inotropic effects of alpha-adrenergic stimulation using a novel, potent, selective membrane-permeable blocker of IP(3) receptor, xestospongin C. Guinea-pig papillary muscle permeabilized with saponin exhibited spontaneous
J Gafni et al.
Neuron, 19(3), 723-733 (1997-10-23)
Xestospongins (Xe's) A, C, D, araguspongine B, and demethylxestospongin B, a group of macrocyclic bis-1-oxaquinolizidines isolated from the Australian sponge, Xestospongia species, are shown to be potent blockers of IP3-mediated Ca2+ release from endoplasmic reticulum vesicles of rabbit cerebellum. XeC
Wenbin Zhong et al.
Nature communications, 7, 12702-12702 (2016-09-02)
Metabolic pathways are reprogrammed in cancer to support cell survival. Here, we report that T-cell acute lymphoblastic leukemia (T-ALL) cells are characterized by increased oxidative phosphorylation and robust ATP production. We demonstrate that ORP4L is expressed in T-ALL but not
Global Trade Item Number
| SKU | GTIN |
|---|---|
| X2628-10UG | 04061837545474 |
| X2628-50UG | 04061833632710 |