Skip to Content
Merck
CN

Z0153

ZM 241385

≥98% (HPLC), adenosine A2A antagonist, powder

Synonym(s):

4-(-2-[7-amino-2-{2-furyl}{1,2,4}triazolo{2,3-a} {1,3,5}triazin-5-yl-amino]ethyl)phenol

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C16H15N7O2
CAS Number:
139180-30-6
Molecular Weight:
337.34
UNSPSC Code:
12352200
PubChem Substance ID:
329831597
NACRES:
NA.77
MDL number:
MFCD00908394

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

ZM 241385, ≥98% (HPLC)

SMILES string

Nc1nc(NCCc2ccc(O)cc2)nc3nc(nn13)-c4ccco4

InChI key

PWTBZOIUWZOPFT-UHFFFAOYSA-N

InChI

1S/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22)

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: >15 mg/mL

storage temp.

room temp

Quality Level

100

Looking for similar products? Visit Product Comparison Guide

Related Categories

Biochem/physiol Actions

ZM 241385 is a potent selective adenosine A2A antagonist.
ZM 241385 is a potent selective adenosine A2A antagonist. The A2A receptor plays a role in regulating myocardial oxygen consumption and coronary blood flow and is highly expressed in the brain, where it has important roles in the regulation of glutamate and dopamine release. ZM 241385 has neuroprotective effects and is being investigated for use in Parkinson′s and other neurodegenerative disorders.

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000518454
0000518454
0000514974
0000514971
0000514971

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Tarek K Motawi et al.
Molecular and cellular biochemistry, 465(1-2), 89-102 (2019-12-11)
Parkinson's disease (PD) is the second common age-related neurodegenerative disease. It is characterized by control loss of voluntary movements control, resting tremor, postural instability, bradykinesia, and rigidity. The aim of the present work is to evaluate curcumin, niacin, dopaminergic and
Chiara Zoppellaro et al.
PloS one, 8(8), e72648-e72648 (2013-09-10)
Adenosine plays an important role in regulating intestinal motility and inflammatory processes. Previous studies in rodent models have demonstrated that adenosine metabolism and signalling are altered during chronic intestinal inflammatory diseases. However, the involvement of the adenosinergic system in the
Sergey Ryzhov et al.
Journal of the American Heart Association, 8(13), e010874-e010874 (2019-06-27)
Background Patients resuscitated from cardiac arrest ( CA ) have highly variable neurological, circulatory, and systemic ischemia-reperfusion injuries. After the initial hypoxic-ischemic insult, a cascade of immune and inflammatory responses develops and is often fatal. The role of the immune
Fabrizio Vincenzi et al.
PloS one, 7(6), e39317-e39317 (2012-07-05)
A(3) adenosine receptors (ARs) play a pivotal role in the development of cancer and their activation is involved in the inhibition of tumor growth. The effects of pulsed electromagnetic fields (PEMFs) on cancer have been controversially discussed and the detailed
Nai-Kuei Huang et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 59, 152756-152756 (2019-04-21)
According to Compendium of Materia Medica, Gastrodia elata (GE) Blume as a top grade and frequently prescribed herbal medicine has been used in treating dizziness, headaches, and epilepsy, indicating a neuroprotective effect. Because GE is capable of suppressing a hyperactive
View All Related Papers

Articles

Adenosine Receptors

We offers many products related to adenosine receptors for your research needs.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service